20384-93-4Relevant academic research and scientific papers
Cu(II)/Proline-Catalyzed Reductive Coupling of Sulfuryl Chloride and P(O)-H for P-S-C Bond Formation
Zhang, Xinghua,Wang, Dungai,An, Duo,Han, Boshi,Song, Xiang,Li, Liang,Zhang, Gaoqi,Wang, Lixian
, p. 1532 - 1537 (2018/02/10)
A considerably improved method for the Cu-catalyzed coupling of sulfuryl chloride with P(O)-H was described. Using commercially available l-proline as the ligand decreased the precatalyst loading, broadened the substrate scope and greatly promoted the efficiency of the coupling reaction. Moreover, gram-scale preparation, easy-to handle and recyclable catalyst featured this transformation.
Preparation method of O-alkylphenylthiophosphate
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Paragraph 0080-0083, (2017/09/01)
The invention relates to the technical field of organic synthesis and discloses a preparation method of O-alkylphenylthiophosphate. The preparation method comprises adding sulfonyl chloride and alkyl phenylphosphonite into an organic solvent, adding a copper salt catalyst and L-proline ligand or bipyridyl ligand into the solution, carrying out a reaction process at 50 to 100 DEG C for 2 to 10h, after the reaction, concentrating the reaction solution, and carrying out separation and purification to obtain O-alkylphenylthiophosphate. The cheap and easily available sulfonyl chloride and alkyl phenylphosphonite are used as raw materials, an alkaline environment is avoided, and the product is obtained under the conditions of a catalytic amount of a copper salt and ligands. The preparation method has the advantages of wide application range of a substrate, simple processes, operation convenience, wide substrate range, good yield, and promotion and application feasibility. The product can be used in fields of medicines and pesticides.
THE ISOMERIZATION/CHLORINATION OF O,O-DIALKYL PHENYLTHIOPHOSPHONATES WITH PHOSPHORUS OXYCHLORIDE - A NEW CONVENIENT SYNTHESIS OF S-ALKYL PHENYLTHIOPHOSPHONIC ACID DERIVATIVES
Tang, Chu Chi,Wu, Gui Ping,Huang, Guang Yan,Li, Zhen,Jin, Gui Yu
, p. 159 - 164 (2007/10/02)
A new method for the synthesis of S-alkyl phenylthiophosphonic acid derivatives is reported.The chlorination of O,O-dialkyl phenylthiophosphonates with phosphorus oxychloride proceeds with isomerization to give S-alkyl phenylthiophosphonochloridates, which react further with various nucleophiles in the presence of triethylamine to give the title compounds.Key words: Phosphonothionate; phosphonothiolate; phosphonodithiolate; phosphonamidethiolate; isomerization; chlorination.
