20409-64-7

Upstream product

• 42239-63-4 2-aminophenyl-(thien-2-yl)methanone 
• 188290-36-0 thiophene 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 6933-34-2 (2-methoxyphenyl)thiophen-2-ylmethanone 
• 3437-95-4 2-Iodothiophene 
• 90-02-8 salicylaldehyde 
• 1003-09-4 2-bromothiophene 
• 50817-56-6 [2]thienyl-[2-(toluene-4-sulfonylamino)-phenyl]-ketone 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 108-95-2 phenol 
• 527-72-0 2-thiophenylcarboxylic acid 
• 89-95-2 2-methyl-benzyl alcohol 
• 881-89-0 phenyl thiophene-2-carboxylate 

Downstream Products

• 6933-34-2 (2-methoxyphenyl)thiophen-2-ylmethanone 
• 97034-91-8 2-thienyl 2'-hydroxyphenyl ketone oxime 
• 97035-10-4 C₁₃H₁₁NO₃S 

Relevant academic research and scientific papers

Water-Tolerant ortho-Acylation of Phenols

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Rhodium-Catalyzed Directing-Group-Assisted Aldehydic C–H Arylations with Aryl Halides

A rhodium-catalyzed general protocol for the directing-group-assisted arylation of aromatic aldehydic C–H bonds was developed. This method involves either hydroxy- or amino-group-directed aldehyde C–H arylation with various aryl halides. A broad synthetic scope for the preparation of 2-hydroxybenzophenones was established with electronically variant salicylaldehydes and aryl halides with chemo- and regioselective possibilities. The developed protocol was also applied in the synthesis of medicinally important 3-salicyloylpyridines in high yields.

A concise approach to the preparation of 2-hydroxydiarylketones by an intramolecular acyl radical ipso substitution

Substituted 2-hydroxydiarylketones have been simply prepared using an intramolecular acyl radical [1,6] ipso substitution reaction. (C) 2000 Elsevier Science Ltd.

2-heteroaryl 2-substituted phenylketone derivatives and their inhibitory activity on platelet aggregation

R 68070 and CV-4151 are two compounds possessing both thromboxane synthetase inhibitory activity and thromboxane receptor antagonist properties. 2-Heteroaryl 2-substituted phenylketone derivatives with a partial structural similarity to R 68070 and CV-415

Platelet antiaggregant methoxyphenylthienyl ketoxime ethers: Synthesis and structure-activity relationships

Some new oximinoalkanoic (n = 2,3,4) esters and acids derived from methoxyphenylthienyl ketones have been synthesized and evaluated in vitro for their inhibitory effects on arachidonic acid-induced human platelet aggregation. Of the eighteen oximinoethers