204328-52-9

Upstream product

• 1319189-53-1 C₁₈H₂₃BrO₆ 
• 4152-09-4 N-benzylethylenediamine 
• 2700-22-3 Benzylidenemalononitrile 
• 33512-02-6 3-phenyl-2,2-oxiranedicarbonitrile 
• 6956-56-5 2,2-dimethoxy-1-phenylethanone 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 90915-03-0 3-phenyl-5,6-dihydropyrazin-2(1H)-one 
• 205748-19-2 (R,S)-2-Bromo-2-phenylacetic acid (R)-pantolactone ester 
• 1327310-45-1 (2-ethoxy-(S)-1-methyl-2-oxoethyl) 2-bromo-2-phenylacetate 
• 1192307-86-0 (2-methoxy-2-oxo-(S)-1-phenylethyl) α-bromophenylacetate 
• 4870-65-9 2-bromophenylacetic acid 
• 902778-26-1 1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-O-yl α-bromo-α-phenylacetate 

Relevant academic research and scientific papers

Iridium-Catalyzed Asymmetric Hydrogenation of Unsaturated Piperazin-2-ones

Two different iridium catalyst systems, generated from the ruthenocene-based phosphine-oxazoline ligand tBu-mono-RuPHOX or the diphosphine ligand BINAP, were developed for the asymmetric hydrogenation of 5,6-dihydropyrazin-2(1H)-ones, affording chiral piperazin-2-ones in good yields and with moderate to good ees. Different catalytic behaviors for the hydrogenation of these types of substrate were observed with these two catalyst systems. Our tBu-mono-RuPHOX ligand, which bears a ruthenocene scaffold with planar chirality, was found to be the best ligand for the [Ir(L)(COD)]BArF catalyst system, affording the desired products with up to 94% ee. (Figure presented.).

Asymmetric Epoxidation of Alkylidenemalononitriles: Key Step for One-Pot Approach to Enantioenriched 3-Substituted Piperazin-2-ones

The first enantioselective epoxidation of readily available alkylidenemalononitriles has been developed by using a multifunctional cinchona derived thiourea as the organocatalyst and cumyl hydroperoxide as the oxidant. A new simple one-pot asymmetric epox

Dynamic resolution of α-halo chiral esters for the synthesis of 3-substituted piperazin-2-ones

Dynamic resolution of α-halo esters derived from five chiral alcohols has been investigated in nucleophilic substitution with ethylenediamine nucleophiles. Stereoselective substitution of α-halo esters and following spontaneous cyclization provide a pract