204633-62-5

Basic information

• Product Name: 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-2,5-dihydro-furan-2-yl}-9H-purin-6-ylamine
• CAS NO: 204633-62-5
• Molecular Weight: 553.593
• Mol File: 204633-62-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-2,5-dihydro-furan-2-yl}-9H-purin-6-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-2,5-dihydro-furan-2-yl}-9H-purin-6-ylamine(204633-62-5)
• EPA Substance Registry System: 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-2,5-dihydro-furan-2-yl}-9H-purin-6-ylamine(204633-62-5)

Safety Data

• Hazardous Substances Data: 204633-62-5(Hazardous Substances Data)

Upstream product

• 226415-08-3 N-(9-((2R,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 144924-99-2 N-(9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 136834-21-4 N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)3-fluoro-4-hydroxytetrahydrofuran-2-yl)9H-purin-6yl)benzamide triethylammonium salt 
• 136834-20-3 N-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 204633-61-4 Methanesulfonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-tetrahydro-furan-3-yl ester 

Downstream Products

• 110143-10-7 iodenosine 

Relevant articles and documents

A new synthetic approach to the clinically useful, anti-HIV-active nucleoside, 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (β- FddA). Introduction of a 2'-β-fluoro substituent via inversion of a readily obtainable 2'-α-fluoro isomer

A convenient route to the anti-HIV active compound, 9-(2,3-dideoxy-2- fluoro-β-D-threo-pentofuranosyl)adenine (1, β-FddA) started with the facile introduction of fluorine at C2' from the α-side of protected 9-(β-D- arabinofuranosyl)adenine (ara-A). Inversion of the stereochemistry at C2' was accomplished via a stable vinyl intermediate (6), which underwent stereoselective reduction of the double bond to give the desired 2'-F-threo isomer with the opposite β-fluoro stereochemistry.