144924-99-2

Usage

Uses

Used in Medicinal Chemistry:
N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine is utilized as a building block for the development of antiviral and anticancer agents due to its enhanced interactions with target enzymes and receptors, which may lead to improved pharmacological properties.
Used in Drug Development:
In the pharmaceutical industry, N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine serves as a key component in the design of novel therapeutics, aiming to address unmet medical needs and provide new treatment options for various diseases.
Ongoing research is focused on exploring the biological activity and potential therapeutic uses of N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine, with the ultimate goal of discovering effective treatments for a range of conditions.

Upstream product

• 97614-43-2 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose 
• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 
• 31085-57-1 O^3',O^5',N⁶-Tritrityladenosine 
• 58-61-7 adenosine 
• 135473-17-5 N⁶-benzoyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine 
• 4005-49-6 N-benzoyladenine 
• 20187-82-0 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 226415-08-3 N-(9-((2R,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 1172119-74-2 C₂₇H₃₄FN₇O₅ 
• 1412911-80-8 C₂₉H₄₄FN₅O₄Si₂ 
• 1412911-81-9 C₂₃H₂₈FN₅O₅Si 
• 1412911-85-3 C₁₇H₁₄FN₅O₅ 
• 1048373-98-3 C₂₃H₃₀FN₅O₄Si 
• 4546-72-9 N₆-benzoyl-2'-deoxyadenosine 
• 204633-64-7 Methanesulfonic acid (2R,3R,4S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-tetrahydro-furan-3-yl ester 
• 204633-62-5 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-2,5-dihydro-furan-2-yl}-9H-purin-6-ylamine 
• 110143-10-7 iodenosine 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 

Relevant academic research and scientific papers

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

Synthesis of Rovafovir Etalafenamide (Part IV): Evolution of the Synthetic Process to the Fluorinated Nucleoside Fragment

Fluorinated nucleoside 1 is a key starting material in the synthesis of rovafovir etalafenamide (2), a novel nucleotide reverse transcriptase inhibitor under development at Gilead Sciences for the treatment of HIV. While an initial manufacturing route enabled the production of 1 to support clinical development, alternative approaches were explored to further enhance manufacturing effectiveness, improve processing time, reduce cost, and minimize the environmental impact. Toward this end, two new routes were developed to a key synthetic intermediate, which was converted to 1 using a new protecting group strategy. The new chemistry led to improvements in the manufacturing process while reducing the overall process mass intensity (PMI).

PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS

The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.

INHIBITORS OF S-ADENOSYL-L-METHIONINE DECARBOXYLASE

Novel mechanism-based inhibitors of S-adenosyl-L-methionine decarboxylase are provided. These compounds of formula (1) inhibit the life cycle of trypanosomes, and are useful to treat subjects infected with African trypanosomes. The invention includes pharmaceutical compositions and methods of using the compounds of formula (1).