Bioorganic and Medicinal Chemistry Letters p. 143 - 146 (1998)
Update date:2022-08-03
Topics:
McClure, Kim F.
Axt, Matthew Z.
A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32-3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.
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