204637-85-4

Upstream product

• 622-33-3 N-benzyloxyamine 
• 174265-77-1 1-[2(R)-[1(R)-carboxy-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 110-89-4 piperidine 
• 6851-81-6 1,5,5-trimethylhydantoin 
• 223433-54-3 1-[2(R)-[1(R)-(methoxycarbonyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]-piperidine 
• 159135-61-2 3-bromomethyl-1,5,5-trimethylimidazolidine-2,4-dione 
• 204637-83-2 (R)-3-Benzyloxycarbonyl-3-tert-butoxycarbonyl-2-cyclopentylmethyl-4-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-butyric acid benzyl ester 
• 204637-80-9 (R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 1-tert-butyl ester 
• 204637-77-4 (R)-2-cyclopentyl-methyl-succinic acid 4-tert-butyl ester 
• 174221-32-0 (R)-3-Cyclopentyl-2-hydroxy-propionic acid benzyl ester 
• 204637-84-3 1-[2(R)-[1(R)-(tert-butoxycarbonyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine 
• 204637-81-0 (R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester 
• 204637-79-6 (2R,3R)-2-Cyclopentylmethyl-3-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-tert-butyl ester 

Downstream Products

• 174265-38-4 cipemastat 

Relevant academic research and scientific papers

Process for manufacturing 1-[3-cyclopentyl -2(R)-[1(R)-hydroxycarbamoyl)-2-(3, 4, 4-trimethyl -2, 5-D ioxo-1-imidazolidinyl) ethyl] propionyl] piperidine

A process manufactures of a compound of formula: and unique intermediates.

Process for manufacture of chiral succinic acid derivatives

The present invention is concerned with a process for the manufacture of chiral succinic acid derivatives of formula (I) STR1 wherein R1 is (C1 -C6) alkyl or benzyl, and the novel intermediates used therein.

Alkylation of succinates: Synthesis of Ro 32-3555

A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32-3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.

Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)

A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage protective agent for use in the treatment of rheumatoid- and osteoarthritis.