2054-16-2

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 32349-49-8 1,4-Bis(4-methoxyphenyl)-2,3-diphenyl-1,4-diaza-1,3-butadien 
• 134-81-6 benzil 
• 1363411-36-2 C₁₂H₁₀N₂O 
• 1363411-24-8 C₂₁H₂₂N₂O₃ 
• 1363411-28-2 1-(4-methoxyphenyl)-4-methylene-5-oxo-2-phenylpyrrolidine-2-carbonitrile 
• 1363411-25-9 C₂₃H₂₆N₂O₃ 
• 1363411-16-8 methyl 4-cyano-4-(4-methoxyphenylamino)-2-methylene-4-phenylbutanoate 
• 7472-54-0 N-(p-methoxyphenyl)benzamide 

Relevant academic research and scientific papers

Amidation of aldehydes and alcohols through α-iminonitriles and a sequential oxidative three-component strecker reaction/thio-michael addition/alumina-promoted hydrolysis process to access β-mercaptoamides from aldehydes, amines, and thiols

Mild and general alumina-promoted hydrolysis conditions for converting α-iminonitriles into carboxamides have been developed. In combination with the oxidative three-component Strecker reaction, the one-pot direct amidation of aldehydes and alcohols is reported. Subsequently, an Yb(OTf) 3-catalyzed Michael addition of thiols to α,β-unsaturated α-iminonitriles is reported for the synthesis of β-mercapto-α- iminonitriles. The successful integration of an oxidative Strecker reaction, thio-Michael addition, and neutral-alumina-promoted hydrolysis of β-mercapto-α-iminonitriles into a three-component one-pot process allowed us to develop the direct conversion of amines, aldehydes, and thiols into β-mercaptoamides. All of these procedures were applicable to aromatic and aliphatic amines and aldehydes. First direct: The direct amidation reactions of aldehydes and alcohols were performed in combination with the oxidative three-component synthesis of α-iminonitriles. In addition, β-mercaptoamides were readily accessed from α,β-unsaturated aldehydes, amines, and thiols by a sequential process that involved a three-component Strecker reaction, Yb(OTf)3-catalyzed thio-Michael addition, and hydrolysis of the resulting β-mercapto-α-iminonitriles (see scheme). Copyright

Construction of highly functional α-amino nitriles via a novel multicomponent tandem organocatalytic reaction: A facile access to α-methylene γ-lactams

The first tertiary amine-catalyzed multicomponent tandem Strecker-allylic-alkylation (SAA) reaction has been developed, which provides a facile access to functionalized α-amino nitriles, which could be readily converted into α-methylene-γ-butyrolactams. The Royal Society of Chemistry 2012.