205587-50-4

Upstream product

• 40167-10-0 2-[4-(benzyloxy)phenyl]acetaldehyde 
• 22822-85-1 ethyl sodiodiethylphosphonoacetate 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 61439-59-6 2-(4-benzyloxyphenyl)ethanol 
• 36438-64-9 p-benzyloxystyrene 
• 100-39-0 benzyl bromide 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 4397-53-9 p-benzyloxybenzaldehyde 

Downstream Products

• 62889-58-1 4-(4-hydroxyphenyl)butyric acid ethyl ester 
• 422321-73-1 trans-4-(4-(benzyloxy)phenyl)-2-buten-1-ol 
• 422321-75-3 ethyl (2R,3S)-4-(4'-benzyloxyphenyl)-2,3-dihydroxybutanoate 
• 177959-36-3 (2S,3S)-4-(4'-benzyloxyphenyl)-1,2-epoxy-3-hydroxybutane 
• 422321-77-5 (2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutan-1-ol 
• 177959-34-1 (2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxy-1-p-toluenesulfonyloxybutane 
• 422321-74-2 4-(4'-benzyloxyphenyl)-1-bromobut-2-ene 
• 422321-76-4 ethyl (2R,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutanoate 
• 125251-66-3 Arbutamine hydrochloride 
• 205587-48-0 N-{(R)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-(4-methoxymethoxy-phenyl)-butyramide 
• 205587-49-1 (R)-1-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[4-(4-methoxymethoxy-phenyl)-butylamino]-ethanol 
• 205587-51-5 4-(4-Methoxymethoxy-phenyl)-butyric acid ethyl ester 
• 205587-47-9 4-(4-Methoxymethoxy-phenyl)-butyric acid 

Relevant academic research and scientific papers

THIOARYL DERIVATIVES AS GPR120 AGONISTS

The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.

Asymmetric dihydroxylation and regioselective C-3 indole coupling routes to the anticoccidial antibiotic (+)-diolmycin A2

A highly enantioselective synthesis of (+)-diolmycin A2 starting from 4-hydroxybenzaldehyde and employing the Sharpless asymmetric dihydroxylation and CH3NO2 solvent assisted regioselective C-3 coupling of indole as the key steps is described.

Catalytic asymmetric synthesis of arbutamine

An efficient catalytic asymmetric synthesis of (R)-arbutamine has been achieved using a catalytic asymmetric nitroaldol reaction promoted by a heterobimetallic multifunctional asymmetric catalyst as a key step.