177959-36-3

Upstream product

• 177959-35-2 Toluene-4-sulfonic acid (2S,3S)-4-(4-benzyloxy-phenyl)-2,3-dihydroxy-butyl ester 
• 177959-34-1 (2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxy-1-p-toluenesulfonyloxybutane 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 120186-59-6 (4-(benzyloxy)phenyl)magnesium bromide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 100-39-0 benzyl bromide 
• 40167-10-0 2-[4-(benzyloxy)phenyl]acetaldehyde 
• 422321-74-2 4-(4'-benzyloxyphenyl)-1-bromobut-2-ene 
• 422321-73-1 trans-4-(4-(benzyloxy)phenyl)-2-buten-1-ol 
• 422321-76-4 ethyl (2R,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutanoate 
• 422321-75-3 ethyl (2R,3S)-4-(4'-benzyloxyphenyl)-2,3-dihydroxybutanoate 
• 205587-50-4 (E)-4-(4-benzyloxyphenyl)-2-butenoic acid ethyl ester 
• 422321-77-5 (2S,3S)-4-(4'-benzyloxyphenyl)-2,3-O-isopropylidenedioxybutan-1-ol 
• 36438-64-9 p-benzyloxystyrene 

Downstream Products

• 177959-37-4 (2S,3S)-1-(4-Benzyloxy-phenyl)-4-(1H-indol-3-yl)-butane-2,3-diol 

Relevant academic research and scientific papers

Asymmetric dihydroxylation and regioselective C-3 indole coupling routes to the anticoccidial antibiotic (+)-diolmycin A2

A highly enantioselective synthesis of (+)-diolmycin A2 starting from 4-hydroxybenzaldehyde and employing the Sharpless asymmetric dihydroxylation and CH3NO2 solvent assisted regioselective C-3 coupling of indole as the key steps is described.

Ytterbium(III) trifluoromethanesulfonate catalyzed high pressure reaction of epoxides with indole. An enantioselective synthesis of (+)-diolmycin A2

Epoxide opening reactions with indole are efficiently accelerated under high pressure conditions in the presence of a catalytic amount of ytterbium(III) trifluoromethanesulfonate to afford tryptophol derivatives. The procedure is successfully applied for an enantioselective synthesis of (+)-diolmycin A2.