79991-38-1

Upstream product

• 100-39-0 benzyl bromide 
• 56426-41-6 3-methyl-5-phenylpyrazole 
• 100-44-7 benzyl chloride 
• 20570-96-1 benzylhydrazine dihydrochloride 
• 93-91-4 1-phenylbutan-1,3-dione 
• 95514-24-2 (Z)-1-amino-1-phenyl-1-buten-3-one 
• 32064-65-6 benzylhydrazine oxalate 
• 3347-62-4 5-methyl-3-phenyl-1H-pyrazole 
• 1896-62-4 (E)-benzalacetone 
• 53941-18-7 trans-4-phenyl-3-buten-2-one tosylhydrazone 
• 495-41-0 1-phenylbut-2-en-1-one 

Relevant academic research and scientific papers

Porphyrins with four azole substituents in meso positions: X-ray crystal structure of meso-tetrakis-(1-benzylpyrazol-4-yl)-porphyrin at 200 K

Several new porphyrins have been prepared in improved yields using an established method which was adapted to formylpyrazoles bearing on the pyrazole N1-nitrogen protective groups. The deprotection of N-para-methoxybenzyl and SEM protected meso

Efficient one-pot synthesis of substituted pyrazoles

An efficient, one-pot synthesis of substituted pyrazoles from enones, hydrazides, and halides was developed. In comparison with the classical Knorr pyrazole synthesis, this methodology gave a different type of product (R 3≥R5). A range of substituted pyrazoles were prepared in good to high yields with complete regioselectivity.

Scope and limitations in the regioselective synthesis of 1,3,5-trisubstituted pyrazoles from β-amino enones and hydrazine derivatives. 13C-chemical shift prediction rules for 1,3,5-trisubstituted pyrazoles

β-amino enones react with hydrazine derivatives to give regioselectively 1,3,5-trisubstituted pyrazoles. The synthetic method only presents limitations when the β-substituent of the enone and the hydrazine substituent are bulky or possess an electron withdrawing character. Comparison of the 13C-NMR spectra of the seventy pyrazoles allowed us to estimate a 13C-chemical shift prediction rule for 1,3,5-trisubstituted pyrazoles, with deviations of less than ± 1 ppm.

Orientation de la reaction d'alkylation des pyrazoles dans des conditions neutres et en catalyse par transfert de phase

The N-butylation and N-benzylation of nine pyrazoles bearing different substituents in positions 3 and 5 have been studied in neutral and basic medium (phase transfer catalysis).The orientation of the reaction depends strongly on the method used when the