205759-94-0

Basic information

• Product Name: methyl 4-(p-aminophenyl)butyrate
• Synonyms: methyl 4-(p-aminophenyl)butyrate
• CAS NO: 205759-94-0
• Molecular Weight: 235.283
• Mol File: 205759-94-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 4-(p-aminophenyl)butyrate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(p-aminophenyl)butyrate(205759-94-0)
• EPA Substance Registry System: methyl 4-(p-aminophenyl)butyrate(205759-94-0)

Safety Data

• Hazardous Substances Data: 205759-94-0(Hazardous Substances Data)

Upstream product

• 5473-15-4 4-(4-acetamidophenyl)-4-oxobutanoic acid 
• 103-84-4 Acetanilid 
• 62-53-3 aniline 
• 67-56-1 methanol 
• 15118-60-2 4-(4-aminophenyl)butyric Acid 
• 31815-69-7 4-(acetylamino)benzenebutanoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 97142-80-8 N-[4-(4-Hydroxy-butyl)-phenyl]-acetamide 
• 305-03-3 chlorambucil 
• 79481-83-7 methyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 130198-76-4 methyl 3-<4-phenyl>butyrate 
• 205180-38-7 N-[4-(4-Oxo-butyl)-phenyl]-acetamide 

Relevant articles and documents

A process for synthesizing phenylbutyric acid nitrogen mustard antineoplastic agent

The invention relates to a synthesis process of an antineoplastic drug chlorambucil. The synthesis process comprises the following steps: (1) amino protection reaction; (2) acylation reaction; (3) reduction reaction; (4) carboxyl protection reaction; (5) substitution reaction; (6) chlorination reaction; and (7) deprotection reaction. According to the synthesis process, the amino group is protected by use of acetic anhydride, and then acylation, reduction, carboxyl protection, substitution, chlorination and aqueous hydrochloric acid solution hydrolysis are performed to obtain the chlorambucil. The synthesis process of the antineoplastic drug chlorambucil has the characteristics of low cost, mild reaction conditions, low toxicity, convenience in process operation, and suitability for industrial production.