205999-89-9

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 105-45-3 acetoacetic acid methyl ester 
• 57-13-6 urea 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 21351-39-3 monocarbamide dihydrogen sulfate 
• 619-73-8 4-nitrobenzyl chloride 
• 674-82-8 4-methyleneoxetan-2-one 
• 67-56-1 methanol 
• 104-88-1 4-chlorobenzaldehyde 
• 5315-87-7 4-nitrobenzaldehyde semicarbazone 
• 17356-08-0 thiourea 
• 141-97-9 ethyl acetoacetate 
• 356566-57-9 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 
• 67280-73-3 α-Chlor-p-nitrobenzylisocyanat 

Downstream Products

• 1290616-94-2 C₁₃H₁₅N₃O₃ 
• 123371-45-9 ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 296267-03-3 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid cyclopentyl ester 
• 295344-04-6 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-ethylsulfanyl-ethyl ester 

Relevant academic research and scientific papers

The new life of traditional water treatment flocculant polyaluminum chloride (PAC): A green and efficient micro-nano reactor catalyst in alcohol solvents

Polyaluminum chloride (PAC) is an inorganic polymer material that has the advantages of a simple preparation process and special electronic structure. It is considered to be the most efficient and widely used flocculation material for water treatment. In

Preparation method of 3,4-dihydropyrimidine-2(1H)-one compound

The invention discloses a preparation method of a 3,4-dihydropyrimidine-2(1H)-one compound, wherein the comprises the steps: (1) respectively adding reaction substrate raw materials aromatic aldehydes, 1,3-diketone ester, urea and a trace amount of water

Isolation of polyphenol compounds from olive waste and inhibition of their derivatives for α-glucosidase and α-amylase

Olive waste was used as a sustainable resource because it contained a variety of valuable compounds. The polyphenols active fraction from enrichment by microporous resin and extraction with ethyl acetate were analysed by different chromatographic methods.

CoFe2O4?SiO2-NH2-CoII NPs: An effective magnetically recoverable catalyst for Biginelli reaction

Biginelli reaction entails acid-catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) with simply-accessible initial substances, specifically, aldehyde, urea, and active methylene compound. DHPMs have stimulated a resurgence of attention in the previous two decades because of their broad-ranging pharmacological actions and the existence of varied all-natural products. Currently, green methods to asymmetric Biginelli reaction have been researched for anti-inflammatory DHPMs. In materials chemistry, DHPMs are increasingly decision applications in the creation of materials like polymers, adhesives, fabric dyes, etc. In light of the simplicity by which the Biginelli reaction is conducted, numerous interesting prospects expect its exploitation in variety fields. CoFe2O4?SiO2-NH2-CoII is herein turned out to be an effective catalyst at a three-component Biginelli reaction. The yield of the corresponding DHPMs was rather large (20 cases; average 92 percent). Finally, we herein suggest a procedure that shows lots of advantages and benefits such as the whole lack of solvents, mild reaction conditions, comparatively short reaction times. Also, CoFe2O4?SiO2-NH2-CoII NPs catalyst has been readily recovered from the reaction combination and reused, without the decrease of catalytic action.

Phthalic acid: A green, biodegradable and environmentally benign nature difunctional Br?nsted acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives and substituted dihydro-2-oxypyrroles

Phthalic acid as a green, biodegradable economical and environmentally benign nature catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives via β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions and one-pot four-component domino condensation of substituted dihydro-2-oxypyrrole by reaction of dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature with short reaction times and excellent yields is reported. The most benefits this procedure are such as green, biodegradable, inexpensive and non-toxic catalyst, eco-friendly, high catalytic activity, efficient, easily separation with no column chromatographic separation, simple operational procedures, one-pot, excellent yields, environmentally benign nature.

Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine, a green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives under solvent-free co

Caffeine was found to be a natural and green and biodegradable catalyst for the one-pot, three-component condensation Biginelli reaction of β-keto esters, aromatic aldehydes and urea/thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones/thi

Method for synthesizing 4-aryl-5-methoxycarbonyl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one

The invention relates to a method for synthesizing 4-aryl-5-methoxycarbonyl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one. The method specifically comprises the following steps: with aromatic aldehyde, methyl acetoacetate and urea as a substrate, and DES as a

Method for catalytically synthesizing 3, 4-dihydropyrimidine-2 (1H)-ketone in green manner

The invention discloses green catalytic Biginelli reaction, and discloses a method for synthesizing 3, 4-dihydropyrimidine-2 (1H)-ketone and derivatives thereof by the aid of 'one-pot processes'. Resin D732 is used as a catalyst, ethyl alcohol is used as a solvent, and the usage of the catalyst is 0.2g/1mmoL aldehyde. The method includes carrying out reflux reaction at the temperatures of 78 DEG Cfor 1-5 hours; filtering out the resin after the reaction is completely carried out; cooling filter liquor by the aid of ice water and then carrying out filter, ethyl alcohol re-crystallization and drying to obtain pure products. Compared with the traditional methods for synthesizing 3, 4-dihydropyrimidine-2 (1H)-ketone by the aid of acid used as a catalyst, the method has the obvious advantagesthat reaction conditions are mild, the method is high in efficiency, short in time and easy to operate, only few byproducts can be generated, and the products have good colors and are high in purity;particularly, the resin D732 used as the catalyst is low in cost, easy to prepare, store and transport and good in repeatability, is easily available and is green and environmentally friendly, accordingly, the method has an excellent industrial application prospect, and the like.

BiVO4-NPs: an efficient nano-catalyst for the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives

BiVO4-NPs can be used as an efficient and reusable nano-catalyst for the promotion of the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives. The structures of the products were characteriz

Clean and one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thione derivatives using maleic acid as an efficient and environmentally benign natural di-functional Br?nsted acid catalyst under solvent-free conditions

An efficient synthesis of Biginelli-type compounds using maleic acid as an economical di-functional Br?nsted acid catalyst in a one-pot, three-component reaction of β-ketoesters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) a