52240-85-4Relevant academic research and scientific papers
Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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, (2008/06/13)
Benzene butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromel
Synthesis of 4-[3′-bis(2″-chloroethyl) aminophenyl] -4,4-difluorobutanoic acid [4,4-difluoro-meta-chlorambucil]
Buss, Christopher W.,Coe, Paul L.,Tatlow, John Colin
, p. 119 - 126 (2007/10/03)
The synthetic sequence to make 4-[4′-bis(2″-chloroethyl)aminophenyl]-4,4-difluorobutanoic acid {4,4-difluorochlorambucil} was not taken beyond the intermediate stage involving methyl 4,4-difluoro-4-(4′-aminophenyl) butanoate, since this amine was hydrolytically unstable. Reaction of methyl 4-(3′-nitrophenyl)-4-oxobutanoate with sulfur tetrafluoride, followed by hydrogenation, afforded the stable isomer, methyl 4,4-difluoro-4-(3′-aminophenyl)butanoate. Bis(hydroxyethylation) by treatment with oxirane, conversion of OH to Cl by Ph3P/ CCl4, and then hydrolysis of the ester group, gave 4-[3′-bis(2″-chloroethyl)aminophenyl]-4,4-difluorobutanoic acid {4,4-difluoro-meta-chlorambucil}.
Antiatherosclerotic silanes
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, (2008/06/13)
This invention is concerned with novel 4-[(trialkylsilyl)alkylamino]phenyl compounds and their use as antiatherosclerotic agents.
Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino)phenyl compounds
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, (2008/06/13)
This disclosure describes novel 4-(polyfluoroalkylamino)phenyl compounds useful as hypolipidemic and antiatherosclerotic agents.
2-Substituted-4'-(monoalkylamino)-acetophenones
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, (2008/06/13)
This disclosure describes 2-substituted 4'-(monoalkylamino)-acetophenones useful as hypolipidemic and anti-atherosclerotic agents.
