206753-52-8

Upstream product

• 123-72-8 butyraldehyde 
• 62-53-3 aniline 
• 321860-04-2 N-benzyl-N-(2-oxo-ethyl)-oxalamic acid methyl ester 
• 1664-40-0 N-(2-aminoethyl)benzeneamine 
• 3074-46-2 N-benzyl,N'-phenylpiperazine 
• 92-54-6 4-phenyl-1-piperazine 
• 100-39-0 benzyl bromide 
• 206753-73-3 N-[2-(Benzyl-tert-butoxycarbonyl-amino)-ethyl]-N-phenyl-oxalamic acid methyl ester 
• 206753-50-6 N-(2-tert-Butoxycarbonylamino-ethyl)-N-phenyl-oxalamic acid methyl ester 
• 58077-34-2 N¹-benzyl-N²-phenylethane-1,2-diamine 
• 100-46-9 benzylamine 
• 74518-47-1 l'ester methylique de l'acide N benzylhydroxamique 
• 100-52-7 benzaldehyde 

Downstream Products

• 206753-73-3 N-[2-(Benzyl-tert-butoxycarbonyl-amino)-ethyl]-N-phenyl-oxalamic acid methyl ester 
• 58077-34-2 N¹-benzyl-N²-phenylethane-1,2-diamine 

Relevant academic research and scientific papers

Selective, Catalytic, and Dual C(sp3)-H Oxidation of Piperazines and Morpholines under Transition-Metal-Free Conditions

By using cheap and innocuous reagents, such as NaClO2, NaOCl, and catalytic amounts of TEMPO, a new environmentally friendly protocol for the selective and catalytic TEMPO C(sp3)-H oxidation of piperazines and morpholines to 2,3-diketopiperazines (2,3-DKP) and 3-morpholinones (3-MPs), respectively, has been developed. This novel direct access to 2,3-DKP from piperazines provides significant advantages over the traditional N-monoacylation/intramolecular C-N cyclization procedure. Additionally, by modulating the amounts of TEMPO, 2-alkoxyamino-3-morpholinone can be prepared from morpholine derivatives, which would enable further functionalization at the C2 position of the morpholine skeleton.

Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination-cyclization

Herein we report the efficient syntheses of 1,4-disubstituted-2,3-diketopiperazines and 1,4,5-trisubstituted-2,3-diketopiperazines, which feature a tandem reductive amination and acylation. Aliphatic and aromatic primary amines serve as viable nucleophiles under the mild reaction conditions. (C) 2000 Elsevier Science Ltd.