2068-83-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxy-2-methylpropanoic acid is used as an intermediate compound for the synthesis of various pharmaceuticals. Its presence as a metabolite indicates its potential involvement in metabolic pathways, making it a valuable compound for drug development and research.
Used in Chemical Synthesis:
In the chemical industry, 3-Hydroxy-2-methylpropanoic acid serves as a building block for the synthesis of other organic compounds. Its unique structure allows for the creation of a wide range of products, including specialty chemicals and materials with specific properties.
Used in Research and Development:
3-Hydroxy-2-methylpropanoic acid is utilized as a research tool in the field of biochemistry and molecular biology. Its role as a metabolite of 3-Hydroxyisobutyrate dehydrogenase makes it an essential component in studying enzyme function, metabolic pathways, and related biological processes.
Used in Diagnostic Applications:
Due to its association with specific metabolic pathways, 3-Hydroxy-2-methylpropanoic acid can be employed in the development of diagnostic tools and tests. These tools can help identify and monitor various metabolic disorders and conditions related to the enzyme 3-Hydroxyisobutyrate dehydrogenase.

InChI:InChI=1/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/t3-/m0/s1

Upstream product

• 67-56-1 methanol 
• 2163-42-0 2-methyl-1.3-propanediol 
• 89534-52-1 3-hydroxy-2-methyl-propionic acid ethyl ester 
• 909803-25-4 kaempferol 3-O-β-D-(6-O-3-hydroxyisobutyryl)glucopyranosyl-(1->4)-α-L-rhamnopyaranosyl-7-O-β-D-glucopyranoside 
• 535-11-5 Ethyl 2-bromopropionate 
• 56850-57-8 3-benzyloxy-2-methylpropionic acid 

Downstream Products

• 7623-10-1 2-methyl-3-chloropropionyl chloride 
• 16837-14-2 2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid 
• 79-41-4 poly(methacrylic acid) 
• 80657-57-4 3-hydroxy-(2S)-methylpropionate 
• 72657-23-9 methyl (R)-3-hydroxy-2-methylpropionate 
• 53009-01-1 β-phenylcarbamoyloxy-isobutyric acid 

Relevant academic research and scientific papers

Palladium-catalyzed β-acyloxylation of simple amide via sp3 C-H activation

β-Acyloxy amides are prepared in moderate to high yields by palladium-catalyzed acyloxylation of primary sp3 C-H bonds from simple amides without any special directing group. A catalytic system of Pd(OAc)2/CF3CO2H/ K2S2O8 is available to various amides with N-substituted by linear alkanes, cyclic alkanes, and electron-deficient benzyl compounds in this reaction. Acyloxylated products could be transformed easily to the corresponding β-hydroxy amides.

Solvent effect and reactivity trend in the aerobic oxidation of 1,3-propanediols over gold supported on titania: Nmr diffusion and relaxation studies

In recent work, it was reported that changes in solvent composition, precisely the addition of water, significantly inhibits the catalytic activity of Au/TiO2 catalyst in the aerobic oxidation of 1,4-butanediol in methanol due to changes in diffusion and adsorption properties of the reactant. In order to understand whether the inhibition mechanism of water on diol oxidation in methanol is generally valid, the solvent effect on the aerobic catalytic oxidation of 1,3-propanediol and its two methyl-substituted homologues, 2-methyl-1,3-propanediol and 2,2-dimethyl-1,3-propanediol, over a Au/TiO2 catalyst has been studied here using conventional catalytic reaction monitoring in combination with pulsed-field gradient nuclear magnetic resonance (PFG-NMR) diffusion and NMR relaxation time measurements. Diol conversion is significantly lower when water is present in the initial diol/methanol mixture. A reactivity trend within the group of diols was also observed. Combined NMR diffusion and relaxation time measurements suggest that molecular diffusion and, in particular, the relative strength of diol adsorption, are important factors in determining the conversion. These results highlight NMR diffusion and relaxation techniques as novel, non-invasive characterisation tools for catalytic materials, which complement conventional reaction data. In solvent company: The solvent effect on the aerobic catalytic oxidation of 1,3-propanediol and its two methyl-substituted homologues, 2-methyl-1,3-propanediol and 2,2-dimethyl-1,3-propanediol, over a Au/TiO 2 catalyst has been studied. The results show that diol conversion is significantly lower when water is present in the initial diol/methanol mixture. A reactivity trend within the group of diols was also observed. Copyright

Cu(I)-catalyzed oxidative cyclization of alkynyl oxiranes and oxetanes

In the presence of a Cu(I) catalyst and a pyridine oxide, alkynyl oxiranes and oxetanes can be converted into functionalized five- or six-membered α,β-unsaturated lactones or dihydrofuranaldehydes. This new oxidative cyclization is proposed to proceed via an unusual allenyloxypyridinium intermediate.

Oxidative esterification of homologous 1,3-propanediols

The oxidative esterification of a homologous series of diols (1,3-propanediol,2-methyl-propanediol and 2,2-dimethyl-1,3-propanediol) with methanol has been investigated using titania-supported gold, palladium and gold-palladium catalysts using molecular oxygen. The gold-palladium catalysts showed the highest activity and 1,3-propanediol was the most reactive while the additional methyl groups decreased the reactivity. However, it is possible to achieve high selectivity to methyl 3-hydroxypropionate and 2-methyl-3- hydroxyisobutyrate by mono-oxidations. Graphical Abstract: [Figure not available: see fulltext.]

Bioactive constituents from chinese natural medicines. XXXI.1 hepatoprotective principles from sinocrassula indica: Structures of sinocrassosides A8, A9, A10, A11, and A12

The methanolic extract from the whole plant of Sinocrassula indica (Crassulaceae) was found to show hepatoprotective effect on D-galactosamineinduced cytotoxicity in primary cultured mouse hepatocytes. From the methanolic extract, five new acylated flavon