4270-73-9

Usage

General Description

1,3-Propanediol, 2-methyl-2-[(phenylmethoxy)methyl]- is a chemical compound that is commonly used as a solvent and intermediate in various industrial processes. It is a clear, colorless liquid with a mild, sweet odor, and it is soluble in water. 1,3-Propanediol, 2-methyl-2-[(phenylmethoxy)methyl]- is used in the production of polymers, such as polyesters and polyurethanes, as well as in the synthesis of pharmaceuticals and pesticides. It is also utilized as a coating additive and a lubricant, and it has potential applications in the manufacture of personal care products and cosmetics. However, it is important to handle this chemical with care, as it can be hazardous if ingested or inhaled, and it may cause irritation to the skin and eyes.

Upstream product

• 77-85-0 2-(hydroxymethyl)-2-methylpropane-1,3-diol 
• 100-52-7 benzaldehyde 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 207850-04-2 5-methyl-2-phenyl-1,3-dioxane-5-carboxylic acid 
• 6103-22-6 5-hydroxymethyl-5-methyl-2-phenyl[1,3]dioxane 
• 3587-60-8 Benzyloxymethyl chloride 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 3663-46-5 5-hydroxymethyl-2,2,5-trimethyl-1,3-dioxane 

Downstream Products

• 171416-30-1 diethyl 5-benzyloxymethyl-5-methyl-3,7-dioxanonanedioate 
• 746692-81-9 C₃₆H₄₈N₃O₉P₃ 
• 151801-12-6 3-(7-benzyloxy-2,5-dioxaheptyl)-3-methyl-1,5,8,11-tetraoxacyclotridecane 
• 1361013-99-1 2-benzyloxymethyl-2-methylmalonaldehyde 

Relevant academic research and scientific papers

Selective monobenzylation of 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) to yield an AB linear monomer and analogous linear oligomers

The synthesis of a mono-benzylated AB monomer based on bis-MPA is explored and accomplished via a three-step synthesis without column chromatography. This optimized synthesis utilizes a generic acid-catalyzed esterification of bis-MPA to the ethyl ester.

Novel synthesis method of ester free trimethylene carbonate derivatives

Ester free poly(trimethylene carbonate) (PTMC) derivatives show biocompatibility and biodegradability and do not generate any acidic compounds after decomposition. Their syntheses methods are limited however, hampering their material application. Herein, we established a novel synthesis route of ester free trimethylene carbonate (TMC) derivatives. The novel synthesis route was described using six aldehydes and one ketone as starting compounds. The key reaction is the selective deprotection from two protected hydroxyl groups in the cyclic acetal structure by diisobutylaluminium hydride. This novel synthesis route means that it is possible to convert aldehyde group to ether groups in the side chain of TMC. Conventionally, only a substituent derived from a primary alcohol was introduced into the side chain. We therefore succeeded in decreasing the number of reaction steps from five to three, compared with the conventional route. Furthermore, the development of a novel synthesis route enabled the introduction of substituents derived from secondary alcohols, anticipating the creation of further types of ester free TMC derivatives.

MANUFACTURING METHOD OF TRIMETHYLENE CARBONATE DERIVATIVE

PROBLEM TO BE SOLVED: To enable easily synthesizing a trimethylene carbonate derivative containing no ester bond. SOLUTION: The manufacturing method of a trimethylene carbonate derivative having a process for obtaining a compound A represented by the following formula (2) by protecting hydroxyl groups at 2 locations of trimethylolalkane represented by the following formula (1) by a protection agent at same time, a process for obtaining a compound B represented by the formula (3) and having 2 hydroxyl groups by reducing the compound A by a reductant and deprotecting only one of the 2 locations, a process for obtaining a trimethylene carbonate derivative represented by the formula (4) by carbonylating 2 hydroxyl groups of the compound B. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Synthesis and evaluation of 1,2-trans alkyl galactofuranoside mimetics as mycobacteriostatic agents

The simple octyl β-d-galactofuranoside was previously described as a good bacteriostatic agent against Mycobacterium smegmatis, a non-pathogenic model of M. tuberculosis. In order to decipher its mechanism of action, STD NMR on whole M. smegmatis cells wa

Stereoarrays with an all-carbon quaternary center: Diastereoselective desymmetrization of prochiral malonaldehydes

Tamed by chelation: The MgBr2 chelation of prochiral malonaldehydes allows diastereoselective monoaddition reactions with allyl stannane nucleophiles (see scheme; PG=protecting group, TBDMS=tert- butyldiphenylmethylsilyl, Tr=trityl). In the same pot, addition of a second nucleophile proceeds in high diastereoselectivity to generate nonsymmetric products with up to five contiguous stereogenic centers, including a chiral all-carbon quaternary center. Copyright

Aliphatic polycarbonates produced from the coupling of carbon dioxide and oxetanes and their depolymerization via cyclic carbonate formation

The (salen)CrCl/onium salt catalyzed coupling reactions of several oxetane derivatives and carbon dioxide are reported. The oxetanes investigated contain substituents in the 3-position covering a range of steric requirements. The oxetanes examined include, 3,3-dimethyloxetane, 3-methoxymethyl-3-methyloxetane, and 3-benzyloxymethyl-3-methyloxetane. The rates of reaction of these oxetanes with CO2 were found to be significantly slower than the corresponding process with the parent oxetane monomer. Furthermore, in these instances the formation of copolymer was found to proceed via the preformed cycloaddition product, i.e., the six-membered cyclic carbonate, to a greater extent and increasing with the steric bulk of the substituents on oxetane. For these sterically more hindered oxetanes, the CO2 coupling reaction carried out in toluene at 110 °C reached an equilibrium product distribution of copolymer to cyclic carbonate which increased in cyclic carbonate product with increasing steric requirements of the oxetane monomer. For example, the catalyzed coupling of the parent oxetane and CO2 provides a copolymer to cyclic carbonate ratio of greater than 95%, whereas the corresponding product distribution for 3-benzyloxymethyl-3-methyloxetane was observed to be 60%. The catalytic rate of depolymerization of a purified sample of the copolymer afforded from 3-benzyloxymethyl-3-methyloxetane and CO2 to the corresponding cyclic carbonate, 5-benzyloxymethyl-5-methyl-1,3-dioxan-2-one, was found to be greatly retarded when carried out in an atmosphere of CO 2.

Polymeric compositions and composites prepared from spiroorthocarbonates and epoxy monomers

Polymeric compositions are provided which are the reaction product of spiroorthocarbonates and epoxy resins and undergo reduced bulk polymerization shrinkage. The spiroorthocarbonates are of the general formula: STR1 wherein X=O or S; R1, and R

Lithium selective ionophores based on pendant arm substituted crown ethers

Ligands have been synthesised which offer good selectivity for lithium ions over sodium based on substituted 14-crown-4 derivatives which bear diamide groups on the ethylene chain or, less effectively, on the central carbon of the propylene chain.The behaviour of potentiometric membrane electrodes based on these ionophores is compared.

A Novel Chiral Building Block with Neopentane Framework for Synthesis: Chemo-Enzymatic Preparation of (R)-CH3C(CH2OSO2CF3)(CH2Cl)(CH2Br)

The pig liver esterase (PLE) catalysed hydrolysis of the prochiral malonic ester (BzlOCH2)(Me)C(COOMe)2 (1) leads to its chiral monoester 2 in selectivities up to 81percent ee.Compound 2 is an ideal entry point for the enantioselective synthesis of 1,1',1