20921-00-0

Basic information

• Product Name: 6-BroMochroMan-2-one
• Synonyms: 6-BroMochroMan-2-one
• CAS NO: 20921-00-0
• Molecular Formula: C₉H₇BrO₂
• Molecular Weight: 227.05468
• Mol File: 20921-00-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 329.5°Cat760mmHg
• Flash Point: 153.1°C
• Appearance: /
• Density: 1.621g/cm³
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 6-BroMochroMan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BroMochroMan-2-one(20921-00-0)
• EPA Substance Registry System: 6-BroMochroMan-2-one(20921-00-0)

Safety Data

• Hazardous Substances Data: 20921-00-0(Hazardous Substances Data)

Usage

General Description

6-Bromochroman-2-one, also known as 6-Bromo-2H-1-benzopyran-2-one, is a chemical compound with the molecular formula C9H5BrO2. It belongs to the class of organic compounds known as coumarins and derivatives. 6-bromochroman-2-one is a yellow solid with a sweet, herbaceous odor. It is primarily used in the synthesis of various pharmaceuticals and agrochemicals, as well as in research and development of new chemical entities. 6-Bromochroman-2-one has also been studied for its potential antioxidant and anti-inflammatory properties, making it an interesting compound for further pharmacological research.

Upstream product

• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 
• 495-78-3 3-(2-hydroxyphenyl)propionic acid 
• 34598-49-7 5-Bromo-1-indanone 
• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 92569-86-3 5-bromo-2-hydroxycinnamaldehyde 
• 19063-55-9 6-bromo-2H-chromen-2-one 
• 7017-52-9 4-bromo-2-(chloromethyl)-1-methoxybenzene 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 82547-30-6 3-(5-bromo-2-methoxyphenyl) propanoic acid 
• 749878-59-9 3-(5-bromo-2-hydroxy-phenyl)-propionic acid 

Downstream Products

• 128652-06-2 6-phenylethynyl-3,4-dihydro-2H-1-benzopyran-2-one 
• 113334-66-0 6-phenyl-3,4-dihydro-2H-1-benzopyran-2-one 
• 128652-00-6 ethyl 6-(3,4-dihydro-2H-1-benzopyran-2-one)propenoate 
• 128652-01-7 ethyl (3-N,N'-diethylpropanamide-4-hydroxyphenyl)propenoate 
• 128652-07-3 butyl (5-bromo-2-hydroxyphenyl)propionate 
• 128652-08-4 butyl (3-butoxycarbonyl-6-hydroxyphenyl)propionate 
• 128652-09-5 C₃₂H₄₂O₉ 
• 33567-65-6 4-bromo-2-(3-hydroxypropyl)phenol 
• 893426-64-7 6-(1-hydroxy-2-(4-pentyl-2-fluorophenyl)ethyl)-3,4-dihydrocoumarin 
• 128652-04-0 methyl(5-hydroxy-3-trimethylsilylethynylphenyl)propionate 
• 1360054-35-8 (E)-4-bromo-2-(5-hydroxypent-3-enyl)phenol 
• 1360054-11-0 (E)-5-(5-bromo-2-hydroxyphenyl)pent-2-enyl 2,2,2-trichloroacetimidate 
• 1360054-22-3 (E)-5-(5-bromo-2-hydroxyphenyl)pent-2-enyl acetate 
• 61370-75-0 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde 

Relevant articles and documents

Manufacturing Process Development for Belzutifan, Part 1: A Concise Synthesis of the Indanone Starting Material

A four-step synthesis of the indanone core of belzutifan (MK-6482) is described. This route starts from the commodity raw material dihydrocoumarin and was successfully demonstrated on a large scale to produce indanone 11 in the synthesis of belzutifan, an FDA-approved first-in-class therapy for the treatment of patients with certain types of Von Hippel-Lindau disease-associated tumors.

SYNTHESIS OF TERPHENYL COMPOUNDS

The present invention relates novel methods of synthesizing terphenyl compounds and in particular to novel methods for the synthesis of a compound of Formula I or intermediates thereof.

Enantioselective Synthesis of Chromenes via a Palladium-Catalyzed Asymmetric Redox-Relay Heck Reaction

A palladium-catalyzed asymmetric redox-relay Heck reaction of 4H-chromenes and arylboronic acids has been successfully developed. The reaction proceeded in moderate to good yields with good to high enantioselectivities. The resulting product is an advanced intermediate of bio-active compound BW683C.