614-70-0

Usage

Uses

Used in Chemical Synthesis Industry:
o-(Ethylamino)phenol is used as a key intermediate in the synthesis of dyes and pigments, contributing to the coloration and stability of these products.
Used in Pharmaceutical Industry:
o-(Ethylamino)phenol is utilized as a building block in the development of pharmaceuticals, potentially enhancing the efficacy of certain medications.
Used in Antioxidant and Antimicrobial Applications:
o-(Ethylamino)phenol has been studied for its potential as an antioxidant, which could protect against oxidative stress, and as an antimicrobial agent, which may help combat microbial infections.
However, due to its toxic nature, o-(ethylamino)phenol requires careful handling and containment to prevent adverse health effects on individuals and the environment.

InChI:InChI=1/C8H11NO/c1-2-9-7-5-3-4-6-8(7)10/h3-6,9-10H,2H2,1H3

Upstream product

• 59-49-4 2-Benzoxazolinone 
• 64-67-5 diethyl sulfate 
• 59130-68-6 N,N,O-Triacetyl-2-aminophenol 
• 87271-57-6 1-Ethyl-1-(2-hydroxy-phenyl)-urea 
• 7647-01-0 hydrogenchloride 
• 30741-06-1 N-ethyl benzoxazol-2-one 
• 40888-01-5 3-ethylbenzo[d]oxazole-2(3H)-thione 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 7664-93-9 sulfuric acid 
• 614-80-2 2-(acetylamino)phenol 
• 74-96-4 ethyl bromide 
• 95-55-6 2-amino-phenol 
• 75-05-8 acetonitrile 
• 88-75-5 2-hydroxynitrobenzene 

Downstream Products

• 103095-87-0 acetic acid-(N-ethyl-2-hydroxy-anilide) 
• 87671-61-2 2-ethoxy-3-ethyl-2,3-dihydro-2,2-diphenyl-1,3,2-benzoxazaphosph(V)ole 
• 87671-63-4 3-ethyl-2,3-dihydro-2-neopentoxy-2,2-diphenyl-1,3,2-benzoxazaphosph(V)ole 
• 630402-99-2 5-benzoyl-furan-2-carboxylic acid ethyl-(2-hydroxy-phenyl)-amide 
• 2814-60-0 2,2'-azino-bis(3-ethylbenzothiazoline) 
• 136273-52-4 C₂₀H₁₈NO₅P 
• 87671-72-5 2-ethylaminophenyl diphenylphosphinate 
• 75-04-7 ethylamine 
• 20934-81-0 4-(benzo[d]oxazol-2-yl)aniline 

Relevant academic research and scientific papers

Preparation method of 2, 2'-azino-bis(3-alkylbenzothiazoline-6-sulfonic acid) salt

The invention discloses a preparation method of a 2, 2'-azino-bis(3-alkylbenzothiazoline-6-sulfonic acid) salt. The raw materials used in the preparation method are easily available, and the price islow, the production cost can be greatly reduced while ensuring a high reaction yield, so that enlarged production is facilitated, meanwhile, the preparation method is different from the previous new preparation process, and the new preparation process is beneficial to academic research, industrial research and practice of ABTS in the field, so that the development of related technologies and related industrial economy in the field is promoted.

Ru-Catalyzed Deoxygenative Transfer Hydrogenation of Amides to Amines with Formic Acid/Triethylamine

A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)2(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway. (Figure presented.).

B(C6F5)3-Catalyzed Deoxygenative Reduction of Amides to Amines with Ammonia Borane

The first B(C6F5)3-catalyzed deoxygenative reduction of amides into the corresponding amines with readily accessible and stable ammonia borane (AB) as a reducing agent under mild reaction conditions is reported. This metal-free protocol provides facile access to a wide range of structurally diverse amine products in good to excellent yields, and various functional groups including those that are reduction-sensitive were well tolerated. This new method is also applicable to chiral amide substrates without erosion of the enantiomeric purity. The role of BF3 ? OEt2 co-catalyst in this reaction is to activate the amide carbonyl group via the in situ formation of an amide-boron adduct. (Figure presented.).

Synthesis of Emissive Heteroacene Derivatives via Nucleophilic Aromatic Substitution

A synthetic approach for preparing a variety of heterocyclic tetrahydropentacene derivatives via nucleophilic aromatic substitution reactions of bidentate nucleophiles and tetrafluoroterephthalonitrile was developed. X-ray crystallography of several products revealed that the compounds containing oxygen and nitrogen heteroatoms are highly planar and engage in π-stacking, while the compounds containing sulfur are bent and do not stack as effectively. The compounds were also highly emissive, and the heteroatom had a significant impact on the emission and electrochemical properties.

Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas

Diethylenetriamine is effective for the direct cleavage of unactivated carbamates and ureas without additional reagents and catalysts. Various carbamates and ureas were cleaved to afford products in good yield, and the reactions were not affected by air or moisture. Unique chemoselective cleavage of carbamate and urea in the presence of amides was also achieved.

Deoxygenative Hydrogenation of Amides Catalyzed by a Well-Defined Iridium Pincer Complex

The iridium-catalyzed highly chemoselective hydrogenation of amides to amines has been developed. Using a well-defined iridium catalyst bearing a P(O)C(O)P pincer ligand combined with B(C6F5)3, the C-O cleavage products are formed under mild reaction conditions. The reaction provides a new method for the preparation of amines from amides in good yield with high selectivity.

Boron Lewis Acid Promoted Ruthenium-Catalyzed Hydrogenation of Amides: An Efficient Approach to Secondary Amines

The hydrogenation of amides to amines has been developed by using the catalyst [Ru(H)2(CO)(Triphos)] (Triphos=1,1,1-tri(diphenylphosphinomethyl)ethane) and catalytic boron Lewis acids such as B(C6F5)3 or BF3?Et2O as additives. The reaction provides an efficient method for the preparation of secondary amines from amides in good yields with high selectivity.

One-pot reductive mono-n-alkylation of aromatic nitro compounds using nitriles as alkylating reagents

A one-pot, simple, selective, and efficient protocol for the synthesis of aromatic secondary amines from various nitro arenes and nitriles in the presence of 10% Pd/C catalyst under H2 at atmospheric pressure and ambient temperature in tetrahydrofuran is illustrated. The scope and limitations of this method have been examined.

Hydroxylation directe d'anilines en aminophenols

Anilines react with hydrogen peroxide in SbF5-HF to give aminophenols.The formation of the products can be accounted for by the reaction of the electrophile H3O2+ on the anilinium ions.For compounds 1a-4a, the reaction yields three possible aminophenols, the meta isomer being the major product.The process is more selective with ortho toluidine 5a and para toluidine 6a, giving aminophenol(s) 5c (42percent)) and 5e (21percent), and 6c (71percent), respectively.With meta toluidine 7a, only aminophenol 7d (35percent) can be isolated from the complex reaction mixture, ring substitution pattern of the substrate favoring para hydroxylation.

DIRECT CONVERSION OF ANILINES INTO AMINOPHENOLS

Hydroxylation of anilines by hydrogen peroxide in SbF5-HF yields the three possible aminophenols, the meta isomer being the major product.The reaction implies attack of protonated hydrogen peroxide H3O2(1+) on the N-protonated substrate.