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209983-91-5

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General Description

"(S)-3-Amino-1-benzyl-azepan-2-one is a chemical compound with the molecular formula C14H18N2O. (S)-3-AMINO-1-BENZYL-AZEPAN-2-ONE falls under the category of azepanes, which are organic cyclic compounds containing seven-membered saturated heterocyclic substance. The presence of a benzyl group signifies that the compound is an alkyl aromatic chemical, imbuing it with specific reactivity and behavior. This particular compound also features an amino and a ketone group, suggesting it could hold potential applications in a variety of chemical reactions, including those in the field of pharmaceutical and medicinal chemistry. The (S)-3-Amino-1-benzyl-azepan-2-one is chiral in nature due to the presence of a stereogenic center, leading to the existence of distinct 'right-handed' and 'left-handed' forms. However, the specific properties and applications of this compound can vary and should be explored in context.

Check Digit Verification of cas no

The CAS Registry Mumber 209983-91-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,9,8 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 209983-91:
(8*2)+(7*0)+(6*9)+(5*9)+(4*8)+(3*3)+(2*9)+(1*1)=175
175 % 10 = 5
So 209983-91-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H18N2O/c14-12-8-4-5-9-15(13(12)16)10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,14H2/t12-/m0/s1

209983-91-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S)-3-amino-1-benzylazepan-2-one

1.2 Other means of identification

Product number -
Other names l-a-amino-e-n-benzyl-caprolactam

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:209983-91-5 SDS

209983-91-5Downstream Products

209983-91-5Relevant articles and documents

Synthesis of bengamide E analogues and their cytotoxic activity

Phi, Thi Dao,Mai, Huong Doan Thi,Tran, Van Hieu,Vu, Van Loi,Truong, Bich Ngan,Tran, Tuan Anh,Chau, Van Minh,Pham, Van Cuong

supporting information, p. 1830 - 1833 (2017/04/21)

A series of bengamide E analogues were prepared from the corresponding polyketide chain and amino acids via amide coupling reactions. Opening of the polyketide chain lactone ring with α-aminolactams was successfully achieved under microwave irradiation in the presence of sodium 2-ethyl hexanoate. A cytotoxic activity evaluation against a panel of cancer cell lines (KB, HepG-2, Lu-1, MCF-7, HL-60 and Hela) indicated that the 2′R analogues were generally more cytotoxic than the 2′S analogues. Additionally, several analogues exhibited selective inhibition against various cancer cell lines: compounds 32a and 32b selectively inhibited MCF-7 cells, while 33b and 35b were more sensitive toward Lu-1 and HepG-2, respectively. Notably, some of the synthetic analogues possess cytotoxic activities with IC50 values less than 1?μM.

Parallel liquid synthesis of N,N′-disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors

Le Diguarher, Thierry,Ortuno, Jean-Claude,Dorey, Gilbert,Shanks, David,Guilbaud, Nicolas,Pierre, Alain,Fauchere, Jean-Luc,Hickman, John A.,Tucker, Gordon C.,Casara, Patrick J.

, p. 3193 - 3204 (2007/10/03)

A rapid structure-activity study was performed by parallel liquid synthesis on N,N′-disubstitution of 3-amino azepin-2-one to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities. The activities of the selected compounds were validated in vivo, and compounds 41a and 44a presented significant antitumour activity.

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