56625-03-7

Basic information

• Product Name: N-(pyridin-2-ylmethyl)formamide
• CAS NO: 56625-03-7
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.1512
• Mol File: 56625-03-7.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 346.6°C at 760 mmHg
• Flash Point: 163.4°C
• Density: 1.119g/cm³
• Vapor Pressure: 5.7E-05mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: N-(pyridin-2-ylmethyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(pyridin-2-ylmethyl)formamide(56625-03-7)
• EPA Substance Registry System: N-(pyridin-2-ylmethyl)formamide(56625-03-7)

Safety Data

• Hazardous Substances Data: 56625-03-7(Hazardous Substances Data)

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 64-18-6 formic acid 
• 109-94-4 formic acid ethyl ester 
• 50-00-0 formaldehyd 
• 67-56-1 methanol 
• 77287-34-4 formamide 
• 124-38-9 carbon dioxide 
• 2258-42-6 formyl acetic anhydride 
• 201230-82-2 carbon monoxide 

Downstream Products

• 274-47-5 imidazo[1,5-a]pyridine 
• 42182-32-1 2-(N-Methyl-N-formyl-aminomethyl)-pyridin 
• 21035-59-6 N-methyl-2-pyridinemethanamine 
• 23950-04-1 a-Nicotine 
• 173344-98-4 1-acetylimidazo<1,5-a>pyridine 

Relevant articles and documents

Chromium-catalysed efficient: N -formylation of amines with a recyclable polyoxometalate-supported green catalyst

A simple and efficient protocol for the formylation of amines with formic acid, catalyzed by a polyoxometalate-based chromium catalyst, is described. Notably, this method shows excellent activity and chemoselectivity for the formylation of primary amines; diamines have also been successfully employed. Importantly, the chromium catalyst is potentially non-toxic, environmentally benign and safer than the widely used high valence chromium catalysts such as CrO3 and K2Cr2O7. The catalyst can be recycled several times with a negligible impact on activity. Finally, a plausible mechanism is provided based on the observation of intermediate and control experiments.

METHOD OF CARBON MONOXIDE FIXATION AND METHOD OF AMINE FORMYLATION

The present invention relates to a method for fixing carbon monoxide in a metal-free condition and a method for formating amine using the same.

Copper-Catalyzed Formylation of Amines by using Methanol as the C1 Source

Cu/TEMPO catalyst systems are known for the selective transformation of alcohols to aldehydes, as well as for the simultaneous coupling of alcohols and amines to imines under oxidative conditions. In this study, such a Cu/TEMPO catalyst system is found to catalyze the N-formylation of a variety of amines by initial oxidative activation of methanol as the carbonyl source via formaldehyde and formation of N,O-hemiacetals and oxidation of the latter under very mild conditions. A vast range of amines, including aromatic and aliphatic, primary and secondary, and linear and cyclic amines are formylated under these conditions with good to excellent yields. Moreover, paraformaldehyde can be used instead of methanol for the N-formylation.