210580-12-4

Basic information

• Product Name: 3-oxo-5-phenyl-4S-(tritylamino)pentanoic acid allyl ester
• CAS NO: 210580-12-4
• Molecular Weight: 489.614
• Mol File: 210580-12-4.mol

Chemical Properties

• CAS DataBase Reference: 3-oxo-5-phenyl-4S-(tritylamino)pentanoic acid allyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-oxo-5-phenyl-4S-(tritylamino)pentanoic acid allyl ester(210580-12-4)
• EPA Substance Registry System: 3-oxo-5-phenyl-4S-(tritylamino)pentanoic acid allyl ester(210580-12-4)

Safety Data

• Hazardous Substances Data: 210580-12-4(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 47672-25-3 N-trityl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 591-87-7 Allyl acetate 

Downstream Products

• 210580-16-8 (2R,5S)-4-Oxo-6-phenyl-2-propyl-5-(trityl-amino)-hexanoic acid methyl ester 
• 1027936-13-5 (Z)-(2R,5S)-6-Phenyl-2-propyl-4-trimethylsilanyloxy-5-(trityl-amino)-hex-3-enoic acid methyl ester 
• 1026285-44-8 (2S,3S)-1-Phenyl-2-(trityl-amino)-undecan-3-ol 
• 387866-80-0 1-phenyl-2S-(tritylamino)undecan-3-one 

Relevant articles and documents

Highly stereoselective syntheses of syn- and anti-1,2-amino alcohols

The reduction of N-protected amino ketones can be carried stereoselectively to produce either the syn- or anti-amino alcohol diastereomer. Carbamate-protected amino ketones can be reduced predictably and selectively to anti-amino alcohols with LiAlH(O-t-Bu)3 in ethanol at -78°C. N-Trityl-protected amino ketones can be reduced selectively to syn-amino alcohols with LiAlH(O-t-Bu)3 in THF at -5°C.

A stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres

A simple, stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres has been developed. N-Tritylated ketomethylene dipeptide isosteres, prepared from N-tritylated amino acids, are converted to their Z- TMS enol ethers and fluorinated with Selectfluor. There is cooperative stereocontrol between the N-tritylamine group and the alkyl group at C-2. The method is short (six steps), diastereoselective (85 → 95%), and enantioselective (>95%).

A stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres

A simple, stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres has been developed. The method is short (6 steps) and diastereoselective (85-95% de) and enantioselective (>95% ee).