210626-65-6

Basic information

• Product Name: (2-methylethyl) (S)-5-hydroxy-3-oxo-5-phenylpentanoate
• Synonyms: (2-methylethyl) (S)-5-hydroxy-3-oxo-5-phenylpentanoate
• CAS NO: 210626-65-6
• Molecular Weight: 250.295
• Mol File: 210626-65-6.mol

Chemical Properties

• CAS DataBase Reference: (2-methylethyl) (S)-5-hydroxy-3-oxo-5-phenylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylethyl) (S)-5-hydroxy-3-oxo-5-phenylpentanoate(210626-65-6)
• EPA Substance Registry System: (2-methylethyl) (S)-5-hydroxy-3-oxo-5-phenylpentanoate(210626-65-6)

Safety Data

• Hazardous Substances Data: 210626-65-6(Hazardous Substances Data)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 100-52-7 benzaldehyde 
• 67-63-0 isopropyl alcohol 
• 546-68-9 titanium(IV)isopropoxide 

Relevant articles and documents

Complete reversal of enantioselection using oxazoline-containing Schiff base ligands derived from l-serine in enantioselective addition of diketene to aldehydes

Starting from one stereogenic center (in this case from l-serine), we obtained two chiral Schiff bases possessing oxazoline moieties, each of which recognized a different enantioface of aldehydes with a high enantiomeric excess [up to 93% ee (R) and 89% e

The asymmetric Maitland-Japp reaction and its application to the construction of the C1-C19 bis-pyran unit of phorboxazole B

The synthesis of the C1-C19 bis-pyran unit of phorboxazole B has been achieved. The key pyran rings were constructed by means of an asymmetric Maitland-Japp reaction and a second Maitland-Japp resolution/cyclization reaction. The longest linear sequence w

Enantioselective addition of diketene to aldehydes promoted by chiral Schiff base-titanium alkoxide complex. Application to asymmetric synthesis of potential inhibitors of HMG coenzyme reductase

Highly enantioselective addition of diketene to aldehydes was achieved by using novel Schiff base-titanium alkoxide complexes. Up to 92% ee of 5-hydroxy-3-oxoesters was obtained. This procedure provides an efficient method for the asymmetric synthesis of potential inhibitors of HMG coenzyme reductase.

Catalytic enantioselective reaction of diketene with aldehydes catalyzed by chiral Schiff base-titanium alkoxide complexes

The catalytic enantioselective reaction of diketene with aldehydes was achieved by the use of a catalytic amount (20 mol%) of chiral Schiff base to afford the corresponding 5-hydroxy-3-oxoesters with high enantioselectivity.

Highly efficient preparation of optically active 5-hydroxy-3-oxoesters by enantioselective reaction of diketene with aldehydes promoted by novel chiral Schiff base-titanium alkoxide complexes

Optically active 5-hydroxy-3-oxoesters 1 can be obtained in up to 91% enantiomeric excess (e.e.) by the enantioselective reaction of diketene with aldehydes promoted by novel chiral Schiff base-titanium alkoxide complexes.