21081-94-7

Basic information

• Product Name: Phosphinothioic acid, diphenyl-, S-(4-chlorophenyl) ester
• CAS NO: 21081-94-7
• Molecular Formula: C18H14ClOPS
• Molecular Weight: 344.801
• Mol File: 21081-94-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Phosphinothioic acid, diphenyl-, S-(4-chlorophenyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinothioic acid, diphenyl-, S-(4-chlorophenyl) ester(21081-94-7)
• EPA Substance Registry System: Phosphinothioic acid, diphenyl-, S-(4-chlorophenyl) ester(21081-94-7)

Safety Data

• Hazardous Substances Data: 21081-94-7(Hazardous Substances Data)

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 1499-21-4 Diphenylphosphinic chloride 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 4559-70-0 Diphenylphosphine oxide 
• 1079-66-9 chloro-diphenylphosphine 
• 5138-90-9 sodium 4-chlorobenzenesulfonate 
• 719-80-2 Ethyl diphenylphosphinite 
• 829-85-6 diphenylphosphane 
• 42839-20-3 1-((4-chlorophenyl)thio)pyrrolidine-2,5-dione 
• 108-86-1 bromobenzene 
• 75980-60-8 (2,4,6-trimethylbenzoyl)diphenylphosphine oxide 
• 100-03-8 4-chlorobenzenesulfinic acid 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 98-66-8 4-chloro-benzenesulfonic acid 
• 1707-03-5 diphenyl-phosphinic acid 

Relevant articles and documents

Electrochemical Enabled Cascade Phosphorylation of N?H/O?H/S?H Bonds with P?H Compounds: An Efficient Access to P(O)-X Bonds

An electrochemical three component cascade phosphorylation reaction of various heteroatoms-containing nucleophiles including carbazoles, indoles, phenols, alcohols, and thiols with Ph2PH has been established. Electricity is used as the “traceless” oxidant and water and air are utilized as the “green” oxygen source. All kinds of structurally diverse organophosphorus compounds with P(O)-N/P(O)-O/P(O)-S bonds are assembled in moderate to excellent yields (three categories of phosphorylation products, 50 examples, up to 97 % yield). A tentative free radical course is put forward to rationalize the reaction procedure.

An Alternative Metal-Free Aerobic Oxidative Cross-Dehydrogenative Coupling of Sulfonyl Hydrazides with Secondary Phosphine Oxides

An alternative metal-free, efficient and practical approach for the preparation of phosphinothioates is established via the aerobic oxidative cross-dehydrogenative coupling (CDC) of sulfonyl hydrazides with secondary phosphine oxides catalyzed by tetrabutylammonium iodide (TBAI) in the presence of atmospheric oxygen. The strategy provides an array of diverse phosphinothioates in good to excellent yields. Furthermore, two representative bioactive molecules are synthesized on up to gram scale by utilizing this method.

Synthetic method of diphenyl thiophosphate compound

The invention discloses a synthesis method of a diphenyl thiophosphate compound. The preparation method comprises the following steps: by taking thiophenol as a reaction substrate and trichloroisocyanuric acid (TCCA) as an accelerant, reacting the reaction substrate and the accelerant in an organic solvent under the conditions of normal temperature and normal pressure for 10 minutes, then adding alkoxy diphenyl phosphine, continuously reacting for 10 minutes, and after the reaction is finished, carrying out separation treatment to obtain the diphenyl thiophosphate compound. According to the synthesis method disclosed by the invention, the reaction is carried out at normal temperature and normal pressure without special requirements; the reaction time is short; and high product yield is achieved.