21136-32-3Relevant articles and documents
Oxidation of 1,1-Disubstituted Hydrazines to Tetrazenes with Benzeneseleninic Acid
Back, Thomas G.
, p. 530 - 531 (1981)
The oxidation of 1,1-disubstituted hydrazines with benzeneseleninic acid in methanol affords the corresponding tetrazenes in high yield.
Visible-light-enabled C(sp2)-H difluoroalkylation of aldehyde-derived hydrazones under metal-free conditions
Liu, Wen-Qiang,Chen, Wei-Hao,Li, Xiao-Xuan,Tang, Wei-Ke,Tao, Ting-Ting,Feng, Yi-Si
, p. 570 - 581 (2019/08/01)
A Eosin Y-catalyzed C(sp2)-H difluoromethylation of aldehyde-derived hydrazones between difluoroalkyl bromides and aldehyde-derived hydrazones is reported. This reaction has a wide range of substrates and occurs under metal-free condition. A me
Asymmetric 1,2-Perfluoroalkyl Migration: Easy Access to Enantioenriched α-Hydroxy-α-perfluoroalkyl Esters
Wang, Pan,Feng, Liang-Wen,Wang, Lijia,Li, Jun-Fang,Liao, Saihu,Tang, Yong
supporting information, p. 4626 - 4629 (2015/04/27)
This study has led to the development of a novel, highly efficient, 1,2-perfluoro-alkyl/-aryl migration process in reactions of hydrate of 1-perfluoro-alkyl/-aryl-1,2-diketones with alcohols, which are promoted by a Zn(II)/bisoxazoline and form α-perfluoro-alkyl/-aryl-substituted α-hydroxy esters. With (-)-8-phenylmenthol as the alcohol, the corresponding menthol esters are generated in high yields with excellent levels of diastereoselectivity. The mechanistic studies show that the benzilic ester-type rearrangement reaction takes place via an unusual 1,2-migration of electron-deficient trifluoromethyl group rather than the phenyl group. The overall process serves as a novel, efficient, and simple approach for the synthesis of highly enantioenriched, biologically relevant α-hydroxy-α-perfluoroalkyl carboxylic acid derivatives.