21222-05-9

Usage

Chemical Properties

White solid

Upstream product

• 119-61-9 benzophenone 
• 180407-30-1 1,1-dichloro-2,2-bis-(3-nitro-phenyl)-ethene 
• 2243-80-3 3-nitrobenzophenone 
• 201230-82-2 carbon monoxide 
• 2865-17-0 m-nitrophenylmercury(II) chloride 
• 67-56-1 methanol 
• 13331-27-6 m-nitrobenzene boronic acid 
• 167284-99-3 1,1,1-trichloro-2,2-bis-(3-nitro-phenyl)-ethane 
• 40490-41-3 3,3'-dinitrothiobenzophenone S-oxide 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 4164-43-6 bis(3-nitrophenyl)methane 
• 64-19-7 acetic acid 
• 2235-01-0 dimethoxydiphenylmethane 

Downstream Products

• 303756-75-4 bis(3-nitrophenyl)methanone oxime 
• 51339-33-4 3,3′-dinitrobenzhydrol 
• 611-79-0 3,3'-diaminobenzophenone 
• 146028-45-7 3,3'-dinitrothiobenzophenone 
• 28437-49-2 1,1-Bis-(3-nitro-phenyl)-propin-⁽²⁾-ol-⁽¹⁾ 
• 116545-05-2 Bis(3-nitrophenyl)dimethoxymethane 
• 120553-13-1 3,3-bis (3-Nitrophenyl)-2-propenal 
• 13005-30-6 1,1'-bis(3-nitrophenyl)ethene 
• 146470-20-4 C₁₄H₁₂N₆O₄*ClH 
• 6602-73-9 <6,6-Bis-(3-nitro-phenyl)-<2>fulvenyl>-bis-(3-nitro-phenyl)-methanol 
• 86457-78-5 1-Chloro-2,2-bis(3-nitrophenyl)-1-phenylethene 
• 121-92-6 3-nitrobenzoic acid 
• 112028-53-2 3,3'-diazidobenzophenone 
• 144791-89-9 1,1'-bis(3-aminophenyl)ethene 

Relevant academic research and scientific papers

Hypervalent iodine in synthesis. 83. Palladium-catalyzed carbonylative coupling of diaryliodonium salts mediated by indium

In the presence of palladium catalyst and indium diaryl-iodonium salt; react with carbon monoxide under mild reaction conditions to give diaryl ketone; in moderate yields.

Palladium imine-pyridine-imine complex immobilized on graphene oxide as a recyclable catalyst for the carbonylative homo-coupling of aryl halides

A heterogeneous 3-N,N,N-(II) Pd(OAc)2 catalyst was prepared from the reaction of Pd(OAc)2 with Si-Prn-N = C-Py-C = N-Prn-Si immobilized on graphene oxide (GO-Si-Prn-N = C-Py-C = N-Prn-Si-GO). The prepared catalyst was characterized by inductively coupled plasma optical emission spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, UV-vis spectroscopy, BET surface area, scanning electron microscopy, transmission electron microscopy, and thermogravimetric analysis. The catalyst was employed as a heterogeneous catalyst for carbonylative homo-coupling of aryl iodides and bromides under carbon monoxide gas-free condition. Cr(CO)6 was used as the carbon monoxide source and the desired symmetrical diaryl ketones were achieved in good to excellent yields. Moreover, the catalyst was reused up to five consecutive cycles without significant loss of activity.

AZA-PYRIDONE COMPOUNDS AND USES THEREOF

Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compound. Examples of an orthomyxovirus viral infection include an influenza infection.

Pd/Cu-cocatalyzed aerobic oxidative carbonylative homocoupling of arylboronic acids and CO: A highly selective approach to diaryl ketones

A highly selective Pd/Cu-cocatalyzed aerobic oxidative carbonylative homocoupling of arylboronic acids has been developed. This method employs a simple catalytic system, readily available boronic acids as the substrates, molecular oxygen as the oxidant, and 1 atm of CO/O2, which makes this method practical for further applications.

Synthesis and characterization of symmetrical eight aromatic ring containing bent-shaped material derived from benzophenone

A new family of symmetrical eight aromatic ring-containing bent-shaped mesogens in which the central elbow is a ketone has been synthesized and characterized. The effect of the side chain on the mesomorphism has been studied. All the bent derivatives were found to exhibit mesomorphism. The higher homologues of the series exhibit the B1 phase and the lower homologues of the series show the B6 phase. Copyright Taylor & Francis Group, LLC.

Synthesis and characterization of banana-shaped mesogens derived from a benzophenone moiety

A homologous series of Schiff's bases consisting of a benzophenone moiety as the central core has been synthesized. Schiff's bases were prepared starting from benzophenone by a sequence of reactions, viz., nitration followed by reduction and heating the r

A facile, catalytic deoximation method using potassium bromide and ammonium heptamolybdate in the presence of hydrogen peroxide in an aqueous medium

A simple, mild and efficient procedure for the cleavage of a wide range of ketoximes and aldoximes to the corresponding carbonyl compounds in an aqueous medium using catalytic amounts of potassium bromide and ammonium heptamolybdate tetrahydrate in combination with 30% hydrogen peroxide is described. Georg Thieme Verlag Stuttgart.

Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase

Steroid sulfatase (STS) is an important new therapeutic target in oncology. Attempts to design nonsteroidal STS inhibitors, because of the oestrogenicity of the original lead oestrone 3-O-sulfamate in rodents, have led to the discovery of benzophenone-4,4′-O,O-bis-sulfamate (BENZOMATE, 3). The nonfused bicyclic BENZOMATE is a highly potent STS inhibitor in vitro, inhibiting STS activity in intact MCF-7 breast cancer cells by >70% at 0.1μM and in placental microsomes by >98% at 10μM. When MCF-7 cells were pre-treated with 3 at 1μM and then washed to remove unbound inhibitor, the initial 94% inhibition was reduced to 89% suggesting that 3, like other sulfamate-based STS inhibitors, inhibits the enzyme irreversibly. This agent also inhibits rat liver STS activity by 84% and 93% respectively 24h after a single dose of 1 or 10mg/kg, demonstrating that BENZOMATE possesses similar in vivo potency to the established potent nonsteroidal inhibitor 667COUMATE. Several modifications were made to BENZOMATE structurally and effects on in vitro activity were examined. These structure-activity relationship studies show that its carbonyl and bis-sulfamate groups are pivotal for activity, although conformational flexibility is not required. Two rigid anthraquinone-based sulfamate derivatives however showed inhibitory activity significantly better than BENZOMATE in the MCF-7 cell assay. BENZOMATE and related analogues therefore represent an important class of non-steroidal STS inhibitor and lead compounds for future drug design.

3,3′-dinitrobenzophenone as a cathode material in a magnesium/zinc based primary battery

The efficiency of 3,3′-dinitrobenzophenone as a cathode material in a magnesium/zinc based primary battery is examnined, The discharge performance of the cell is investigated under different parametric variations such as temperature. nature of electrolyte