21273-08-5

Usage

Uses

Used in Organic Synthesis:
Phenoxyacetic acid trimethylsilyl ester is used as a reagent for the protection of carboxylic acids, enabling selective functional group manipulation in organic synthesis. This protection allows for the controlled formation of esters and amides, which are fundamental to the creation of complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, Phenoxyacetic acid trimethylsilyl ester is employed as a key intermediate in the synthesis of various drugs. Its role in protecting carboxylic acid groups is crucial for the development of new medicinal compounds, ensuring the stability and reactivity necessary for effective drug design.
Used in Agrochemical Production:
Phenoxyacetic acid trimethylsilyl ester is utilized in the production of agrochemicals, such as pesticides and herbicides. Its protective properties allow for the synthesis of active ingredients that are both stable and reactive, contributing to the effectiveness of these agricultural products.
Used in Chemical Research:
As a valuable tool in chemical research, Phenoxyacetic acid trimethylsilyl ester is used to enhance the stability and reactivity of molecules under study. This allows researchers to explore new chemical pathways and develop innovative synthetic methods, furthering the understanding of organic chemistry and its applications.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 122-59-8 2-phenoxyacetic acid 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 16029-98-4 trimethylsilyl iodide 
• 84322-63-4 (trimethoxysilyl)methyl phenoxyacetate 

Downstream Products

• 202998-27-4 (2-hydroxyethyl)trimethylammonium phenoxyacetate 
• 107940-16-9 2-phenoxy-1,1-bis(trimethylsilyloxy)ethene 
• 71617-04-4 1-phenoxyheptan-2-one 
• 721-04-0 2-phenoxy-1-phenylethanone 
• 87683-12-3 α-phenoxy-β-hydroxybutyrolactone 
• 122-59-8 2-phenoxyacetic acid 
• 107959-90-0 2-Phenoxy-2-(trimethylsilyl)ethansaeure-trimethylsilylester 

Relevant academic research and scientific papers

Synthesis of trimethylsilyl carboxylates by HMDS under solvent-free conditions

A broad set of structurally different carboxylic acids were transformed into their trimethylsilyl esters with HMDS in a practically completely solvent-free process, while a catalytic amount of iodine was required in some cases. The process has several advantages over the known methods: untreated reactants, air atmosphere, mild and neutral conditions, no evolution of hydrogen halide, no need of an additional base, low amount of waste, completely without chromatography, low consumption of energy, and operational simplicity.

One-pot synthesis of 3-hydroxymaleic anhydrides by cyclization of 1,1-bis(trimethylsilyloxy)ketene acetals with oxalyl chloride

Functionalized 3-hydroxymaleic anhydrides were prepared by cyclization of 1,1-bis(trimethylsilyloxy)ketene acetals with oxalyl chloride.

Process for preparing acid halides

An improved process for preparing trialkylsilyl ester and acid halide derivatives of carboxylic acids is provided along with novel trialkylsilyl ester intermediates of 2-(2-furyl)-2-methoximinoacetic acid.

1-Substituted-1-oxo-prostane-derivatives of the E, A and F series

The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: STR1 wherein R is C1 to C6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C1 -C4 alkyl, OR16, SR16, F, or Cl, and R16 is C1 to C6 alkyl.