Phenoxyacetic acid trimethylsilyl ester

Base Information

• Chemical Name: Phenoxyacetic acid trimethylsilyl ester
• CAS No.: 21273-08-5
• Molecular Formula: C11H16O3Si
• Molecular Weight: 224.332
• Hs Code.: 2931900090
• Mol file: 21273-08-5.mol

Synonyms:Trimethylsilyl-phenoxyacetat;Trimethylsilyl phenoxyacetate;phenoxy-acetic acid trimethylsilyl ester;2-Phenoxyethansaeure-trimethylsilylester;Acetic acid,phenoxy-,trimethylsilyl ester;

Chemical Property of Phenoxyacetic acid trimethylsilyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 2.44350

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenoxyacetic acid trimethylsilyl ester

There total 4 articles about Phenoxyacetic acid trimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

chloro-trimethyl-silane (75-77-4) + 2-phenoxyacetic acid (122-59-8) → 2-Phenoxyethansaeure-trimethylsilylester (21273-08-5)

Guidance literature:

2-phenoxyacetic acid; With pyridine; In tetrahydrofuran; at 0 ℃; for 0.5h;

chloro-trimethyl-silane; With 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.tet.2007.01.026

Reference yield: 65.0%

trimethylsilyl iodide (16029-98-4) + (trimethoxysilyl)methyl phenoxyacetate (84322-63-4) → 2-Phenoxyethansaeure-trimethylsilylester (21273-08-5) + C8H23IO3Si3 + (iodomethyl)tris(trimethylsiloxy)silane + C10H25IO5Si3 + C12H31IO5Si4 + methyl iodide (74-88-4)

Guidance literature:

Product distribution; Heating; var. ratio of reactants;

Reference yield: 20.0%

1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) + 2-phenoxyacetic acid (122-59-8) → 2-Phenoxyethansaeure-trimethylsilylester (21273-08-5)

Guidance literature:

With iodine; In neat (no solvent); at 20 ℃; for 48h; Green chemistry;

DOI:10.1016/j.tet.2016.08.003

upstream raw materials:

chloro-trimethyl-silane

2-phenoxyacetic acid

trimethylsilyl iodide

(trimethoxysilyl)methyl phenoxyacetate

Downstream raw materials:

2-phenoxy-1,1-bis(trimethylsilyloxy)ethene

2-Phenoxy-2-(trimethylsilyl)ethansaeure-trimethylsilylester

α-phenoxy-β-hydroxybutyrolactone

(2-hydroxyethyl)trimethylammonium phenoxyacetate