Bioorganic and Medicinal Chemistry Letters p. 1997 - 2000 (1998)
Update date:2022-08-04
Topics:
Shirai, Ryuichi
Takayama, Hisae
Nishikawa, Asuka
Koiso, Yukiko
Hashimoto, Yuichi
The (S,S)-enantiomer of combretadioxolane (3), designed as a chirally preorganized derivative of combretastatin A-4, exhibited quite strong tubulin polymerization-inhibitory activity (IC50: 4-6 μM). (S,S)-3 is 20 times more potent than vincristine as an in vitro growth inhibitor (in terms of GI50) of the multi-drug-resistant (MDR) cell line PC-12, which produces P- glycoprotein.
View Morewebsite:http://www.shochem.com
Contact:021-50800795
Address:No.1043, Halei Rd, Zhangjiang Hi-Tech Park, Shanghai, Postcode 201203, China
YingYing Pharmaceutical Co.,Ltd
Contact:86-18854126208
Address:55#, yingxiongshan road
Xi'an Costrong Pharmaceutical Co., Ltd.
Contact:029- 68576496
Address:Room 2004,Shuibao Building,No.190,South Erhuan Rd, Yanta District,Xi'an,Shaan Xi,China
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
website:http://www.trustwe.com
Contact:+86-21-61551413
Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong
Contact:886 2 2541 0022
Address:8 Fl., No. 11, Sec. 1, Chung Shan North Rd., Taipei, Taiwan R.O.C.
Doi:10.1246/bcsj.41.2807
(1968)Doi:10.1039/a804425b
(1998)Doi:10.1016/S0960-894X(00)00346-2
(2000)Doi:10.1039/a803099e
(1998)Doi:10.1016/S0040-4039(00)75547-X
(1968)Doi:10.1016/j.polymer.2010.10.045
(2010)
