2136287-66-4Relevant academic research and scientific papers
Preparation method of balosavir intermediate
-
, (2021/02/13)
The invention discloses a preparation method of a balosavir intermediate, and particularly relates to a method for efficiently synthesizing 7, 8-difluorodibenzo[B, E]thieno-11(6H)one by taking 2, 3-difluorotoluene as a raw material through three steps of
Method for synthesizing heterocyclic compound
-
, (2021/09/08)
The invention relates to a synthetic method of a heterocyclic compound, and belongs to the field of pharmaceutical chemistry. The heterocyclic compound can be synthesized by Grignard reaction of a raw material followed by condensation, and the obtained pr
Preparation method of sulfur-containing hetero-seven-membered ring compound
-
Paragraph 0043-0044; 0059-0063, (2021/06/13)
The invention relates to a preparation method of a sulfur-containing hetero-seven-membered ring compound. The method comprises the following steps: carrying out halogenation reaction, nucleophilic substitution, acylation, cyclization, reduction and the li
Dibenzo seven-membered ring derivative as well as preparation method and application thereof
-
, (2021/03/31)
The invention relates to a dibenzo seven-membered ring derivative as well as a preparation method and application thereof. The chemical structure of the dibenzo seven-membered ring derivative is shownas a formula (I), and X1 and X2 are respectively and independently selected from H, F, Cl, Br or I. The preparation method has easily available raw materials, and can ensure continuous supply and production; the raw materials are cheap and have the cost advantage; and thiophenol or sodium thiophenol is not used, so that the method is more environment-friendly and is also beneficial to the body health of related personnel. 7,8-difluorodibenzo[b,e]thiazepine-11(6H)-one as one of the products can further react to obtain 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol, and the 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol can be used as an important intermediate for preparing a drug baloxavir, so that baloxavir preparation cost is reduced.
Compound for preparing baloxavir or derivatives thereof as well as preparation method and application of compound
-
Paragraph 0287-0289, (2021/02/10)
The invention relates to a preparation method of a compound shown as a formula VIII for preparing baloxavir or derivatives thereof, a compound shown as a formula I for preparing the compound shown asthe formula VIII and a preparation method of the compound shown as the formula I. The compound shown as the formula I is used for preparing the compound shown as the formula VIII, the baloxavir or thederivative thereof. The preparation method is simple and convenient to operate, and the raw materials are easily available and low in cost; reaction conditions are mild, and the method is safe and environment-friendly; side reactions are few, and the product purity is high; and the quality is controllable, and the method is suitable for industrial production.
Pyridone-containing polycyclic derivative inhibitor as well as preparation method and application thereof
-
Paragraph 0163; 0206-0209, (2021/05/12)
The invention relates to a pyridone-containing polycyclic derivative inhibitor as well as a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method
Xofluza sulfur-containing heterocyclic compound, intermediate and preparation method thereof
-
, (2020/03/17)
The invention discloses an Xofluza sulfur-containing heterocyclic compound, an intermediate and a preparation method thereof, and provides a preparation method of a compound represented by a formula 5. The preparation method is mild in reaction condition,
Preparation method of baloxavir intermediate
-
, (2020/03/17)
The invention relates to a preparation method of a baloxavir intermediate and belongs to the field of medicinal chemistry. With the compound (A) as an initial raw material, the method includes a halogenation reaction, a Grignard reaction, a halogenation r
Substituted dibenzodibenzoylbenzothiepinone [b,e] compound and preparation method (thereof) -11(6H). (by machine translation)
-
Paragraph 0019-0020, (2020/02/14)
The preparation method comprises the following steps, the. preparation method of [b,e] the (substituted) dibenzodibenzothiepenecycloheptacyclopropyl-116( 6H)-ketone compound disclosed, by the invention can be recovered and recycled, and. the yield, and purity, [(of (the) product) obtained] by the method are low by [b,e] a (few) percent. [b,e] (). (by machine translation)
Preparation method of baloxavir key intermediate and intermediate thereof
-
Paragraph 0061-0063; 0070-0071, (2020/11/02)
The invention discloses a preparation method of a baloxavir key intermediate and the intermediate thereof. The method includes subjecting 3,4-difluoro-2-methyl benzaldehyde shown as a formula (I) as araw material to a bromination reaction to obtain 3,4-di
