1985607-83-7

Basic information

• Product Name: Zofluza intermediate
• Synonyms: Zofluza intermediate;CPD1605;7,8-difluoro-6,11-dihydro-Dibenzo[b,e]thiepin-11-ol
• CAS NO: 1985607-83-7
• Molecular Formula: C14H10F2OS
• Molecular Weight: 264.29
• EINECS: -0
• Mol File: 1985607-83-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 379.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.400±0.06 g/cm3(Predicted)
• PKA: 12.57±0.20(Predicted)
• CAS DataBase Reference: Zofluza intermediate(CAS DataBase Reference)
• NIST Chemistry Reference: Zofluza intermediate(1985607-83-7)
• EPA Substance Registry System: Zofluza intermediate(1985607-83-7)

Safety Data

• Hazardous Substances Data: 1985607-83-7(Hazardous Substances Data)

Usage

General Description

Zofluza intermediate refers to an intermediate substance used in the preparation of Zofluza, a prescription medicine used to treat influenza in individuals above the age of 12. Zofluza (otherwise known as Baloxavir Marboxil) works by inhibiting the replication of the influenza virus within the body, thereby easing symptoms and reducing the duration of the illness. The exact chemical structure or process involving the Zofluza intermediate isn't publicly disclosed due to the proprietary nature of pharmaceutical manufacturing. Like many pharmaceutical intermediates, they are valuable for fine-tuning chemical reactions to produce the final active pharmaceutical ingredient (API).

Upstream product

• 882-33-7 diphenyldisulfane 
• 130286-84-9 N,N-diethyl-3,4-difluorobenzamide 
• 847502-84-5 3,4-difluoro-2-methylbenzaldehyde 
• 2136287-66-4 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one 
• 157652-31-8 3,4-difluoro-2-methyl benzoic acid 
• 1807193-48-1 1-bromo-2-(bromomethyl)-3,4-difluorobenzene 
• 651326-72-6 (6-bromo-2,3-difluorophenyl)methanol 
• 108-98-5 thiophenol 
• 160775-14-4 3,4-difluoro-2-methylbenzoic acid methyl ester 
• 3828-49-7 1,2-difluoro-3-methyl-benzene 
• 847502-81-2 1-bromo-3,4-difluoro-2-methyl-benzene 
• 847502-83-4 3,4-difluoro-2-methylbenzonitrile 
• 930-69-8 sodium thiophenolate 
• 2136287-65-3 3,4-difluoro-2-((phenylthio)methyl)benzoic acid 

Downstream Products

• 1985605-59-1 (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 

Relevant articles and documents

Pyridazone derivative and its uses

The present invention belongs to the pharmaceutical field, specifically relates to a pyridazone derivative and its uses, compounds thereof and pharmaceutically acceptable salts, solvates including hydrates, polycrystallines, prodrugs, co-crystallines, tau

Dibenzo seven-membered ring derivative as well as preparation method and application thereof

The invention relates to a dibenzo seven-membered ring derivative as well as a preparation method and application thereof. The chemical structure of the dibenzo seven-membered ring derivative is shownas a formula (I), and X1 and X2 are respectively and independently selected from H, F, Cl, Br or I. The preparation method has easily available raw materials, and can ensure continuous supply and production; the raw materials are cheap and have the cost advantage; and thiophenol or sodium thiophenol is not used, so that the method is more environment-friendly and is also beneficial to the body health of related personnel. 7,8-difluorodibenzo[b,e]thiazepine-11(6H)-one as one of the products can further react to obtain 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol, and the 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol can be used as an important intermediate for preparing a drug baloxavir, so that baloxavir preparation cost is reduced.

Pyridone-containing polycyclic derivative inhibitor as well as preparation method and application thereof

The invention relates to a pyridone-containing polycyclic derivative inhibitor as well as a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method