213834-81-2Relevant articles and documents
6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents
Lin, Chun-Mao,Huang, Sheng-Tung,Lee, Fu-Wei,Kuo, Hsien-Saw,Lin, Mei-Hsiang
, p. 4402 - 4409 (2006)
A series of coumarin derivatives were synthesized in two steps from phloroglucinol. The anti-inflammatory activities of these derivatives were evaluated by means of inhibiting NO production in LPS-induced RAW 264.7 cells. Derivatives 3, 8, 10, 11, and 13 exhibited low micromolar levels of anti-inflammatory activities, and these derivatives also protected DNA against hydroxyl radical attack. Coumarin derivative 8 was the most potent derivative among those tested herein against NO production in LPS-induced RAW 264.7 cells with an IC50 value of 7.6 μM, and it effectively reduced the hydroxyl radical production by 50% at 100 μM in the electron spin resonance study.
Neoflavonoids as inhibitors of HIV-1 replication by targeting the Tat and NF-κB pathways
Olmedo, Dionisio A.,López-Pérez, José Luis,Del Olmo, Esther,Bedoya, Luis M.,Sancho, Rocío,Alcamí, José,Mu?oz, Eduardo,San Feliciano, Arturo,Gupta, Mahabir P.
, (2017/03/08)
Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were teste
Minor coumarins from Calophyllum teysmannii var. inophylloide and synthesis of cytotoxic calanone derivatives
Cao, Shu-Geng,Wu, Xiao-Hua,Sim, Keng-Yeow,Tan, Benny H. K.,Vittal, Jagadese J.,Pereira, Joan T.,Goh, Swee-Hock
, p. 1404 - 1416 (2007/10/03)
A chemotaxonomic survey for biologically active compounds from Malaysian Calophyllum species led to the finding of the four new benzoylcoumarins 1a, 2, 3, and 4a (including the unusual prenylated 6-benzoylcoumarin 1a, two uncommon coumarins 5 and 6a with
