21408-05-9Relevant academic research and scientific papers
gem-cyclodialkylation A facile synthetic route to N-substituted heterocycles
Hargis, Duane C.,Shubkin, Ronald L.
, p. 2991 - 2994 (2007/10/02)
N-alkylated and N-arylated pyrroles, pyrrolidines, and piperidines are synthesized in high yield by the reaction between cyclic ethers and primary amines over a heterogeneous titania catalyst.
N-Alkylation d'amines en catalyse homogene. Synthese de mono- et de diamines cycliques
Bitsi, G.,Schleiffer, E.,Antoni, F.,Jenner, G.
, p. 343 - 352 (2007/10/02)
Ruthenium compounds are appropriate catalysts in the N-alkylation of amines.The synthesis of N-alkylated cyclic amines from a cyclic amine and an alcohol or via the condensation between a diol and a primary amine are described.The reaction with cyclic amines is highly selective, especially in the presence of a phosphine, making it a high yielding preparative procedure.The catalytic condensation between cyclic amines and diols yields either an aminoalcohol (A) or a bicyclic diamine (B).The temperature, the presence of phosphine, and the ratio of amine to diol are decisive in directing the reaction toward A or B.The proposed mechanism involves the dehydrogenation of the alcohol followed by attack of the amine on the aldehyde intermediate.
