2142-65-6

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-[2-(1-methylethyl)phenyl](9CI) is used as a fragrance ingredient and flavoring agent in the pharmaceutical industry. Its strong aromatic odor and solubility properties make it suitable for incorporation into various pharmaceutical products.
Used in Cosmetic Industry:
In the cosmetic industry, Ethanone, 1-[2-(1-methylethyl)phenyl](9CI) is utilized as a fragrance ingredient and flavoring agent. Its aromatic properties enhance the sensory experience of cosmetic products, contributing to their overall appeal.
Used as an Intermediate in Organic Synthesis:
Ethanone, 1-[2-(1-methylethyl)phenyl](9CI) serves as an intermediate in the synthesis of other organic compounds. Its chemical structure allows for further reactions and modifications, making it a valuable component in the creation of new chemical entities for various applications.

InChI:InChI=1/C11H14O/c1-8(2)10-6-4-5-7-11(10)9(3)12/h4-8H,1-3H3

Upstream product

• 75-05-8 acetonitrile 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 1068-55-9 isopropylmagnesium chloride 
• 12203-34-8 (η(6)-iso-propylbenzene)chromium tricarbonyl 
• 2743-00-2 (E)-4-methoxy-N-(1-phenylethylidene)benzenamine 
• 75-26-3 isopropyl bromide 
• 2438-04-2 2-isopropylbenzoic acid 
• 75-16-1 methylmagnesium bromide 
• 75-29-6 isopropyl chloride 

Downstream Products

• 2438-04-2 2-isopropylbenzoic acid 
• 6623-98-9 2-Isopropylbenzoesaeuremethylester 

Relevant academic research and scientific papers

5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY

The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

Direct catalytic cross-coupling of alkenyllithium compounds

A catalytic method for the direct cross-coupling of alkenyllithium reagents with aryl and alkenyl halides is described. The use of a catalyst comprising Pd2(dba)3/XPhos allows for the stereoselective preparation of a wide variety of substituted alkenes in high yields under mild conditions. In addition (1-ethoxyvinyl)lithium can be efficiently converted into substituted vinyl ethers which, after hydrolysis, give readily access to the corresponding methyl ketones in a one pot procedure.

Cobalt-catalyzed chelation-assisted alkylation of arenes with primary and secondary alkyl halides

Cobalt-N-heterocyclic carbene catalytic systems have been developed for chelation-assisted ortho-alkylation of aromatic compounds with alkyl halides. Aryl imines can be selectively monoalkylated at room temperature by various primary or secondary alkyl chlorides or bromides. The catalytic system can also be applied to 2-arylpyridine derivatives, which in the absence of steric hindrance are amenable to dialkylation by an excess of the alkyl halide. Mechanistic experiments, including reactions of stereochemical probes and radical clocks, indicate that the reaction involves single-electron transfer from the cobalt center to the alkyl halide to form the corresponding alkyl radical, which has a finite lifetime before it undergoes C-C bond formation. Georg Thieme Verlag Stuttgart, New York.

Cobalt-catalyzed ortho alkylation of aromatic imines with primary and secondary alkyl halides

We report here cobalt-N-heterocyclic carbene catalytic systems for the ortho alkylation of aromatic imines with alkyl chlorides and bromides, which allows the introduction of a variety of primary and secondary alkyl groups at room temperature. The stereochemical outcomes of the reaction of secondary alkyl halides suggest that the present reaction involves single-electron transfer from a cobalt species to the alkyl halide to generate the corresponding alkyl radical. A cycloalkylated product obtained by this method can be transformed into unique spirocycles through manipulation of the directing and cycloalkyl groups.

Unexpected cross-coupling reaction between o-chloroaryl ketones and organomanganese reagents

(Chemical equation presented) Alkyl- and arylmanganese reagents react with o-chloro or o-bromoaryl ketones to give the substituted ketones in high yields. The cross-coupling reaction is performed under mild conditions (-60 to +40°C, 30 min to 4 h) and tak