2142-67-8

Basic information

• Product Name: 2'-ETHOXYACETOPHENONE
• Synonyms: 2-ACETYLPHENETOLE;2'-ETHOXYACETOPHENONE;2-ETHOXYACETOPHENONE;1-(2-ETHOXYPHENYL)ETHANONE;AKOS BBS-00006696;AURORA 22085;O-ETHOXY ACETOPHENONE;Ethoxyacetophenone
• CAS NO: 2142-67-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);C10;Carbonyl Compounds;Ketones
• Mol File: 2142-67-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 36-40 °C(lit.)
• Boiling Point: 244 °C
• Flash Point: >230 °F
• Appearance: light yellow to colorless liquid
• Density: 1.00
• Vapor Pressure: 0.289mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2'-ETHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-ETHOXYACETOPHENONE(2142-67-8)
• EPA Substance Registry System: 2'-ETHOXYACETOPHENONE(2142-67-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2142-67-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C11H16O/c1-9(2)11-6-4-10(5-7-11)8-12-3/h4-7,9H,8H2,1-3H3

Upstream product

• 40618-55-1 O-ethyl phenylchlorophosphonite 
• 118-93-4 o-hydroxyacetophenone 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 
• 75-36-5 acetyl chloride 
• 103-73-1 Phenetole 
• 74-96-4 ethyl bromide 
• 7647-01-0 hydrogenchloride 
• 103345-89-7 diethyl (2-acetylphenyl)phosphite 
• 103345-86-4 o-acetylphenyl ethyl diethylphosphoramidite 

Downstream Products

• 1092296-98-4 4-(2-ethoxyphenyl)-2-hydroxy-4-oxo-but-2-enoic acid methyl ester 
• 1276115-67-3 4-(2-ethoxybenzoyl)-3-hydroxy-1-(2-hydroxypropyl)-5-(4-isopropylphenyl)-1,5-dihydropyrrol-2-one 
• 1276115-78-6 4-(2-ethoxybenzoyl)-3-hydroxy-1-(3-methoxypropyl)-5-(4-trifluoromethylphenyl)-1,5-dihydropyrrol-2-one 
• 1276115-79-7 4-(2-ethoxybenzoyl)-5-(3-fluoro-4-trifluoromethylphenyl)-3-hydroxy-1-(3-methoxypropyl)-1,5-dihydropyrrol-2-one 
• 938-73-8 2-ethoxybenzamide 
• 139756-21-1 5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one 
• 139755-92-3 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 152074-07-2 2-bromo-1-(2-ethoxyphenyl)ethan-1-one 
• 64015-68-5 (2-ethoxyphenyl)glyoxal 

Relevant articles and documents

Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model

A new series of 1,3-diketone, heterocyclic and α,β-unsaturated derivatives were synthesized and evaluated for their AhR antagonist activity using zebrafish and mammalian cells. Compounds 1b, 2c, 3b and 5b showed significant AhR antagonist activity in a transgenic zebrafish model. Among them, compound 3b, and 5b were found to have excellent AhR antagonist activity with IC50 of 3.36 nM and 8.3 nM in a luciferase reporter gene assay. In stem cell proliferation assay, compound 5b elicited marked HSC expansion.

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis

Recent investigations showed that anandamide, the main endogenous ligand of CB1 and CB2 cannabinoid receptors, possesses analgesic, antidepressant and anti-inflammatory effects. In the perspective to treat inflammatory bowel disease (IBD), our approach was to develop new selective CB2 receptor agonists without psychotropic side effects associated to CB1 receptors. In this purpose, a new series of 3-carboxamido-5- aryl-isoxazoles, never described previously as CB2 receptor agonists, was designed, synthesized and evaluated for their biological activity. The pharmacological results have identified great selective CB2 agonists with in vivo anti-inflammatory activity in a DSS-induced acute colitis mouse model.

NMR and X-ray characterization of the diastereomeric pinacols derived from the photo-irradiation of o-alkoxyacetophenones

A simple 1H NMR characterization of diastereomeric pinacols derived from o-alkoxy-acetophenones is described. The 1H NMR spectral assignments are based on molecular modeling and substantiated by X-ray crystallographic structural assi