2142-67-8

Basic information

• Product Name: 2'-ETHOXYACETOPHENONE
• Synonyms: 2-ACETYLPHENETOLE;2'-ETHOXYACETOPHENONE;2-ETHOXYACETOPHENONE;1-(2-ETHOXYPHENYL)ETHANONE;AKOS BBS-00006696;AURORA 22085;O-ETHOXY ACETOPHENONE;Ethoxyacetophenone
• CAS NO: 2142-67-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);C10;Carbonyl Compounds;Ketones
• Mol File: 2142-67-8.mol

Chemical Properties

• Melting Point: 36-40 °C(lit.)
• Boiling Point: 244 °C
• Flash Point: >230 °F
• Appearance: light yellow to colorless liquid
• Density: 1.00
• Vapor Pressure: 0.289mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2'-ETHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-ETHOXYACETOPHENONE(2142-67-8)
• EPA Substance Registry System: 2'-ETHOXYACETOPHENONE(2142-67-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2142-67-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C11H16O/c1-9(2)11-6-4-10(5-7-11)8-12-3/h4-7,9H,8H2,1-3H3

Upstream product

• 103345-89-7 diethyl (2-acetylphenyl)phosphite 
• 64-17-5 ethanol 
• 118-93-4 o-hydroxyacetophenone 
• 75-36-5 acetyl chloride 
• 103-73-1 Phenetole 
• 74-96-4 ethyl bromide 
• 7647-01-0 hydrogenchloride 
• 75-03-6 ethyl iodide 
• 40618-55-1 O-ethyl phenylchlorophosphonite 
• 103345-86-4 o-acetylphenyl ethyl diethylphosphoramidite 

Downstream Products

• 60159-70-8 1-(2-ethoxyphenyl)butane-1,3-dione 
• 35244-11-2 2'-hydroxyflavone 
• 139756-21-1 5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one 
• 139755-92-3 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 152074-07-2 2-bromo-1-(2-ethoxyphenyl)ethan-1-one 

Relevant articles and documents

Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model

A new series of 1,3-diketone, heterocyclic and α,β-unsaturated derivatives were synthesized and evaluated for their AhR antagonist activity using zebrafish and mammalian cells. Compounds 1b, 2c, 3b and 5b showed significant AhR antagonist activity in a transgenic zebrafish model. Among them, compound 3b, and 5b were found to have excellent AhR antagonist activity with IC50 of 3.36 nM and 8.3 nM in a luciferase reporter gene assay. In stem cell proliferation assay, compound 5b elicited marked HSC expansion.

NADPH OXIDASE INHIBITORS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND APPLICATION THEREOF

The present disclosure relates to a compound of Formula I, or a geometric isomer, enantiomer, diastereomer, racemate, atropisomer, pharmaceutically acceptable salt, prodrug or solvate thereof. The present disclosure further relates to a composition comprising the compound of Formula (I). The compound and the composition described herein can be used to inhibit NADPH oxidase activity.

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis

Recent investigations showed that anandamide, the main endogenous ligand of CB1 and CB2 cannabinoid receptors, possesses analgesic, antidepressant and anti-inflammatory effects. In the perspective to treat inflammatory bowel disease (IBD), our approach was to develop new selective CB2 receptor agonists without psychotropic side effects associated to CB1 receptors. In this purpose, a new series of 3-carboxamido-5- aryl-isoxazoles, never described previously as CB2 receptor agonists, was designed, synthesized and evaluated for their biological activity. The pharmacological results have identified great selective CB2 agonists with in vivo anti-inflammatory activity in a DSS-induced acute colitis mouse model.

Ultrasound assisted Friedel-Crafts acylation of aromatics using ferric sulphate as catalyst

The use of ultrasound in the acylation reactions of various aromatics and polyaromatics with different acyl chlorides, in the presence of catalytic amount of ferric sulphate at room temperature, gives good yields of the respective ketones with a short reaction time. A facile and simple synthesis of various aromatic ketones using Friedel-Crafts acylation has been established from the corresponding acid chlorides and aromatic or polyaromatic compounds, respectively under mild reaction conditions with shorter reaction times (30-45 min) and in reasonable yields. This method offers the advantage of low cost and ease of purification of the products because of the small amount of ferric sulphate used in these reactions.

NMR and X-ray characterization of the diastereomeric pinacols derived from the photo-irradiation of o-alkoxyacetophenones

A simple 1H NMR characterization of diastereomeric pinacols derived from o-alkoxy-acetophenones is described. The 1H NMR spectral assignments are based on molecular modeling and substantiated by X-ray crystallographic structural assi

Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives

Derivatives of phenyl pyridinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.

Photocyclization Reactions. Part 1. Synthesis of Dihydrobenzofuranols Using Photocyclization of 2-Alkoxybenzaldehydes, 2'-Alkoxyacetophenones, 2-Formylphenoxyacetic Acids and 2-Acetylphenoxyacetic Acids

Photocyclization reactions were carried out on 2-alkoxybenzaldehydes 1a-f, 2'-alkoxyacetophenones 2a-h, 2-formylphenoxyacetic acids 1i-l and 2-acetylphenoxyacetic acids 2i-m.Irradiation opf 1a-f and 2a-h in acetonitrile gave the corresponding dihydrobenzofuranols 3, 5 and dihydroisobenzofuranols 4, 6.Using carboxylic acids 1i-l, 2i-m as starting materials, decarboxylation occurred immediately to give the corresponding ethers 1a-d, 2a-e.Further irradiation of the solution afforded dihydrobenzofuranols 3,5 and dihydroisobenzofuranols 4, 6.Substituent effects on photocyclization and reaction pathways are discussed.