21434-18-4

Upstream product

• 64-18-6 formic acid 
• 13207-43-7 2-phenythiosemicarbazide 
• 13423-60-4 1-phenyl-1H-1,2,4-triazole 
• 333-20-0 potassium thioacyanate 
• 6000-60-8 phenylhydrazonoacetic acid 
• 540-72-7 sodium thiocyanide 

Downstream Products

• 31821-63-3 4-phenyl-3-[(phenylmethyl)sulfanyl]-4H-1,2,4-triazole 
• 1204685-92-6 dimethyl 2-[(1-phenyl-1H-1,2,4-triazol-5-yl)sulfanyl]-3-(1,1,1-triphenyl-λ5-phosphanylidene)succinate 
• 1204685-93-7 diethyl 2-[(1-phenyl-1H-1,2,4-triazol-5-yl)sulfanyl]-3-(1,1,1-triphenyl-λ5-phosphanylidene)succinate 
• 42838-39-1 5-methylsulfanyl-1-phenyl-1,2-dihydro-[1,2,4]triazol-3-one 

Relevant academic research and scientific papers

METHOD OF SYNTHESIZING 1,2,4-TRIAZOLE-3-THIONE COMPOUNDS AND INTERMEDIATES THEREOF

Disclosed is a method of synthesizing 1,2,4-triazole-3-thione compounds and intermediates thereof. The method includes reacting a hydrazine with glyoxylic acid to form a hydrazono acetic acid intermediate followed by reacting the latter with thiocyanate to obtain the 1,2,4-triazole-3-thione compound. The raw materials involved in the present method are readily available, and the reaction is very specific in terms of regioselectivity, resulting in minimum by-product and high product yield. There are neither specific requirements for special equipment nor special operations such as high vacuum, high temperature, anhydrous and oxygen-free manipulations. The process is simple and generates minimum wastes, suitable for industrial production.

In situ generation and trapping of aryllithium and arylpotassium species by halogen, sulfur, and carbon electrophiles

(Chemical Equation Presented) A general method has been developed for in situ trapping of arylmetal intermediates by halogen, sulfur, ketone, and aldehyde electrophiles affording the functionalization of the most acidic position in arene. Pentafluorobenzene, benzothiazole, and benzoxazole can be functionalized by using K3PO4 base. For less acidic arenes, tBuOLi base is required. Arenes with DMSO pKa values of 35 or less are reactive. 2009 American Chemical Society.