21434-18-4

Basic information

• Product Name: 3H-1,2,4-Triazole-3-thione, 1,2-dihydro-2-phenyl-
• CAS NO: 21434-18-4
• Molecular Formula: C8H7N3S
• Molecular Weight: 177.23
• Mol File: 21434-18-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3H-1,2,4-Triazole-3-thione, 1,2-dihydro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-1,2,4-Triazole-3-thione, 1,2-dihydro-2-phenyl-(21434-18-4)
• EPA Substance Registry System: 3H-1,2,4-Triazole-3-thione, 1,2-dihydro-2-phenyl-(21434-18-4)

Safety Data

• Hazardous Substances Data: 21434-18-4(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 13207-43-7 2-phenythiosemicarbazide 
• 333-20-0 potassium thioacyanate 
• 6000-60-8 phenylhydrazonoacetic acid 
• 540-72-7 sodium thiocyanide 
• 13423-60-4 1-phenyl-1H-1,2,4-triazole 

Downstream Products

• 42838-39-1 5-methylsulfanyl-1-phenyl-1,2-dihydro-[1,2,4]triazol-3-one 
• 1204685-93-7 diethyl 2-[(1-phenyl-1H-1,2,4-triazol-5-yl)sulfanyl]-3-(1,1,1-triphenyl-λ5-phosphanylidene)succinate 
• 1204685-92-6 dimethyl 2-[(1-phenyl-1H-1,2,4-triazol-5-yl)sulfanyl]-3-(1,1,1-triphenyl-λ5-phosphanylidene)succinate 
• 31821-63-3 4-phenyl-3-[(phenylmethyl)sulfanyl]-4H-1,2,4-triazole 

Relevant articles and documents

METHOD OF SYNTHESIZING 1,2,4-TRIAZOLE-3-THIONE COMPOUNDS AND INTERMEDIATES THEREOF

Disclosed is a method of synthesizing 1,2,4-triazole-3-thione compounds and intermediates thereof. The method includes reacting a hydrazine with glyoxylic acid to form a hydrazono acetic acid intermediate followed by reacting the latter with thiocyanate to obtain the 1,2,4-triazole-3-thione compound. The raw materials involved in the present method are readily available, and the reaction is very specific in terms of regioselectivity, resulting in minimum by-product and high product yield. There are neither specific requirements for special equipment nor special operations such as high vacuum, high temperature, anhydrous and oxygen-free manipulations. The process is simple and generates minimum wastes, suitable for industrial production.