6000-60-8

Basic information

• Product Name: Acetic acid, (phenylhydrazono)- (9CI)
• Synonyms: Acetic acid, (phenylhydrazono)- (9CI)
• CAS NO: 6000-60-8
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.16132
• Product Categories: GLYCINESCAFFOLD
• Mol File: 6000-60-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetic acid, (phenylhydrazono)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, (phenylhydrazono)- (9CI)(6000-60-8)
• EPA Substance Registry System: Acetic acid, (phenylhydrazono)- (9CI)(6000-60-8)

Safety Data

• Hazardous Substances Data: 6000-60-8(Hazardous Substances Data)

Upstream product

• 79-43-6 dichloro-acetic acid 
• 100-63-0 phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 
• 298-12-4 Glyoxilic acid 
• 80447-71-8 phenylhydrazone of ethyl ester of glyoxalic acid 
• 25081-30-5 (N'-phenyl-hydrazino)-acetic acid 
• 2348-70-1 phenylhydrazono-acetonitrile 
• 3255-95-6 phenylhydrazono-acetic acid amide 
• 69676-53-5 2-(hydroxyimino)propanedioic acid 
• 2706-75-4 sodium glyoxylate 
• 100-34-5 benzene diazonium chloride 
• 5335-36-4 ethyl phenylazocyanoacetate 

Downstream Products

• 1885-34-3 N,N'-diphenylformazan 
• 21434-16-2 1-phenyl-4,5-dihydro-1,2,4-triazol-5(1H)-one 
• 223526-96-3 phenylcarbonohydrazonic dibromide 
• 147-82-0 2,4,6-tribromoaniline 
• 29842-04-4 phenylazo-formaldehyde-oxime 
• 21434-18-4 1,2-dihydro-2-phenyl-3H-1,2,4-triazole-3-thione 

Relevant articles and documents

METHOD OF SYNTHESIZING 1,2,4-TRIAZOLE-3-THIONE COMPOUNDS AND INTERMEDIATES THEREOF

Disclosed is a method of synthesizing 1,2,4-triazole-3-thione compounds and intermediates thereof. The method includes reacting a hydrazine with glyoxylic acid to form a hydrazono acetic acid intermediate followed by reacting the latter with thiocyanate to obtain the 1,2,4-triazole-3-thione compound. The raw materials involved in the present method are readily available, and the reaction is very specific in terms of regioselectivity, resulting in minimum by-product and high product yield. There are neither specific requirements for special equipment nor special operations such as high vacuum, high temperature, anhydrous and oxygen-free manipulations. The process is simple and generates minimum wastes, suitable for industrial production.

Design, synthesis and biological activity of novel substituted pyrazole amide derivatives targeting EcR/USP receptor

In order to discover highly active ecdysone analogs, a series of new substituted pyrazole amide derivatives were obtained using structure-guided optimization method and further screened for their insecticidal activities, in the basis of the core structures of the two active compounds N-(3-methoxyphenyl)-3-(tert-butyl)-1-phenyl-1H-pyrazole-5-carboxamide (6e) and N-(4-(tert-butyl)phenyl)-3-(tert-butyl)-1-phenyl-1H-pyrazole-5-carboxamide (6i), previously presented by us. The chemical structures of the title compounds were identified by spectral analyses. The preliminary bioassay results indicated that one among the synthesized pyrazole derivatives, compound 34, endowed with good activity against Mythimna Separata at 10 mg/L, which was equal to that displayed by the positive control tebufenozide. In addition, examples of molecular docking and molecular dynamics studies demonstrated that 34 may be the potential inhibitor to EcR and its docking conformation was similar to that of tebufenozide. In addition, increasing the hydrophobic effect and considering the suitable bulk effect on pyrazole ring are beneficial to the inhibiting activity to EcR and activity in vivo.

Quantification and mass isotopomer profiling of α-keto acids in central carbon metabolism

Mass spectrometry has been established as a powerful and versatile technique for studying cellular metabolism. Applications range from profiling of metabolites to accurate quantification and tracing of stable isotopes through the biochemical reaction netw