475232-32-7

Upstream product

• 1192217-74-5 7-isopropoxy-8-methoxy[1]benzopyrano[3,4-b]pyrrol-4(3H)-one 
• 215715-46-1 1-(α-Iodoacetoxy)-2-[(3-isopropoxy-4-methoxy-phenyl)ethynyl]-5-isopropoxy-4-methoxybenzene 
• 439585-86-1 4-ethynyl-2-isopropoxy-1-methoxybenzene 
• 475232-31-6 formic acid 5-isopropoxy-2-(3-isopropoxy-4-methoxy-phenylethynyl)-4-methoxy-phenyl ester 
• 215715-45-0 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol 
• 215715-44-9 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxybenzaldehyde 
• 215715-43-8 β,β-dibromo-3-isopropoxy-4-methoxystyrene 
• 200941-15-7 2-iodo-5-isopropoxy-4-methoxybenzaldehyde 
• 34123-66-5 O-isopropylisovanillin 
• 621-59-0 isovanillin 
• 215715-41-6 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one 

Downstream Products

• 475232-29-2 3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one 
• 115982-22-4 14-(3,4-dihydroxyphenyl)-2,3,11,12-tetrahydroxy-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one 

Relevant academic research and scientific papers

Synthesis of lamellarins via regioselective assembly of 1,2-diarylated [1]benzopyrano[3,4-b]pyrrol-4(3H)-one core

A modular synthesis of lamellarins has been developed. The key reactions in this synthesis are the assembly of 1,2-diarylated [1]benzopyrano- [3,4-b]pyrrol-4(3H)-ones from a preexisting [1]benzopyrano[3,4-b]pyrrol- 4(3H)-one core and the appropriate arylb

Total synthesis and evaluation of lamellarin α 20-Sulfate analogues

In order to explore the influence of sulfate groups on the bioactivity profiles of marine alkaloids of the lamellarin class, three such alkaloids, lamellarin α lamellarin α 13,20-disulfate and H, were synthesized and their activities against HIV-1 integrase and cancer cell ines were compared with those of lamellarin α 20-sulfate, which is a selective inhibitor of HIV-1 integrase. Lamellarin α does not inhibit HIV-1 integrase but shows moderate cytotoxicity with good cell line selectivity. Lamellarin α13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. Lamellarin H is a more potent inhibitor of HIV-1 integrase but lacked the specificity required to be medicinally useful. Copyright