2158-01-2

Upstream product

• 39078-72-3 S-methyl N-butylthiocarbamate 
• 108-91-8 cyclohexylamine 
• 111-36-4 n-butyl isocyanide 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 13810-02-1 N-hydroxycyclohexanecarboxamide 
• 109-73-9 N-butylamine 
• 25070-80-8 prop-2'-en-1'-yl cyclohexylcarbamate 
• 874394-02-2 2,2,2-trichloroethyl N-cyclohexylcarbamate 
• 124-38-9 carbon dioxide 
• 36323-18-9 N-Methyl-N-p-tosyl-N'-n-butylharnstoff 

Downstream Products

• 827-52-1 1-phenyl-1-cyclohexane 
• 116418-85-0 1-(1-butyl)-3-cyclohexylbarbituric acid 

Relevant academic research and scientific papers

Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines

A novel lanthanum triflate mediated conversion of N -benzyloxycarbonyl-, N -allyloxycarbonyl-, and N -trichloroethoxycarbonyl-protected amines into nonsymmetric ureas was discovered. In this study, lanthanum triflate was found to be an effective catalyst for preparing various nonsymmetric ureas from protected amines. A variety of protected aromatic and aliphatic carbamates reacted readily with various amines in the presence of lanthanum triflate to generate the desired ureas in high yields. This result demonstrated that this novel lanthanum triflate catalyzed preparation of ureas from Cbz, Alloc, and Troc carbamates can be employed for the formation of various urea structures.

Lossen rearrangements under heck reaction conditions

The classical Lossen rearrangement converts activated hydroxamic acids to isocyanates that form numerous products upon their reaction with nucleophiles. We report a simple and highly efficient method of using Heck reaction conditions to initiate Lossen rearrangements of hydroxamic acids. In addition, Lossen rearrangements occur in the presence of palladium(II) acetate or triethylamine, components of the Heck reaction, alone. A potential mechanism is provided to explain this reactivity and these results show that Heck reactions and Lossen rearrangements occur under the same conditions and may provide new methods for facile initiation of Lossen rearrangements.

Synthesis of urea derivatives from amines and CO2 in the absence of catalyst and solvent

Urea derivatives are obtained in mild to good yield from the reactions of primary aliphatic amines with CO2 in the absence of any catalysts, organic solvents or other additives. To optimize reaction conditions, experimental variables including temperature, pressure, the concentration of amine, reaction time etc. were studied. Satisfactory yields were obtained at the optimized conditions that are comparable to the presence of catalyst and solvent. The preliminary investigation of the reaction mechanism showed that alkyl ammonium alkyl carbamate was quickly formed as the intermediate, and then the final product was formed by the intramolecular dehydration.

PTH AGONISTS

This invention relates to uracil-derived compounds of forumlas(I) and (II) which are agonists of the parathyroid hormone type I receptor (PTH1R) and as such are useful for the treament of osteoporosis.

Conversion of carbonimidodithioates into unsymmetrical Di- and Tri- substituted ureas including urea dipeptides

Selective hydrolysis of carbonimidodithioates (3) leads to the thiocarbamates (4), which can be easily transformed to the unsymmetrical ureas (5) by treatmeat with the appropriate amines. This constitutes a synthesis of ureas without the use of phosgene o

1,3 Disubstituted-5-diazobarbituric acids

Disclosed are substituted derivatives of 5-diazobarbituric acid selected from those having the formulas: STR1 wherein R1 and R2 are substituents selected from the group consisting of C3 to C12 alkyl, cyclohexyl,