216019-41-9

Upstream product

• 119008-52-5 (S,S)-2,5-bis(methylsulfonyloxy)hexane 
• 829-85-6 diphenylphosphane 
• 34338-96-0 (2S,5S)-2,5-hexanediol 
• 75-09-2 dichloromethane 
• 55-93-6 1,4-bis(methylsulfonyloxy)-1,4-dimethylbutane 
• 2935-44-6 hexane-2,5-diol 
• 17299-04-6 (2S,5S)-hexane-2,5-diol di-p-toluenesulfonate 
• 65567-06-8 lithium diphenylphosphide 

Relevant academic research and scientific papers

Development of effective bidentate diphosphine ligands of ruthenium catalysts toward practical hydrogenation of carboxylic acids

Hydrogenation of carboxylic acids (CAs) to alcohols represents one of the most ideal reduction methods for utilizing abundant CAs as alternative carbon and energy sources. However, systematic studies on the effects of metal-to-ligand relationships on the catalytic activity of metal complex catalysts are scarce. We previously demonstrated a rational methodology for CA hydrogenation, in which CA-derived cationic metal carboxylate [(PP)M(OCOR)]+ (M = Ru and Re; P = one P coordination) served as the catalyst prototype for CA self-induced CA hydrogenation. Herein, we report systematic trial- and-error studies on how we could achieve higher catalytic activity by modifying the structure of bidentate diphosphine (PP) ligands of molecular Ru catalysts. Carbon chains connecting two P atoms as well as Ar groups substituted on the P atoms of PP ligands were intensively varied, and the induction of active Ru catalysts from precatalyst Ru(acac)3 was surveyed extensively. As a result, the activity and durability of the (PP)Ru catalyst substantially increased compared to those of other molecular Ru catalyst systems, including our original Ru catalysts. The results validate our approach for improving the catalyst performance, which would benefit further advancement of CA self-induced CA hydrogenation.

Ligand substituent effects on asymmetric induction. Effect of structural variations of the DIOP ligand on the Rh-catalyzed asymmetric hydrogenation of enamides

(equation presented) Substituent changes in the ligand (L*) backbone and the chelating phosphorus atoms of the classical DIOP ligand result in dramatic changes in the enantioselectivity of Rh+L*-catalyzed enamide hydrogenations.

Synthesis, determination of enantiomeric purity and structural characterisation of enantiopure (2R,5R)-(+)-2,5-bis-(diphenylphosphino)-hexane, a chiral DPPB analogue

Enantiopure (2R,5R)-(+)-2,5-bis-(diphenylphosphino)hexane, 3, a chiral analogue of 1,4-bis-(diphenylphosphino)butane was synthesized in two steps from enantiomerically pure (2S,5S)-(+)-hexanediol. The molecular structure of (2R,5R)-3 was determined by X-ray structure analysis of its nickel-(II)-complex showing a rare dimeric species; NMR analysis of the reaction product of 3 with (+)-di-μ-chloro-bis-{2-[1-(dimethylamino)ethyl]phenyl-C,N}-dipallad ium allowed to deduce the enantiomeric purity.

An Efficient Procedure for the Synthesis of C-Chiral Bisphosphines.

A practical method for the synthesis of bisphosphines containing homochiral carbon backbones is described.This procedure entails sequential reaction of a homochiral ditosylate with the appropriate dialkyl- or diarylphosphine-borane anion followed by BH3 decomplexation mediated by HBF4*OMe2.

An Efficient Procedure for the Synthesis of Electron Rich Biphosphines Containing Homochiral Backbones.

An eminently practical method for the synthesis of homochiral biphosphines is described.This procedure entails the sequential reaction of homochiral ditosylate with the appropriate dialkylphosphine-borane anion followed by BH3 decomplexation mediated by HBF4*OMe2.

Ruthenium phosphine complex

A ruthenium phosphine complex having catalytic, hydrogenation activity is disclosed. The catalyst as the formula STR1 wherein R and R' are the same or different and are C1 to C6 linear or branched alkyl; R" is hydrogen or C1/su