363-67-7

Usage

Uses

Used in Pharmaceutical Industry:
2,4,6-Cycloheptatrien-1-one, 3,5,7-tribromo-2-hydroxyis used as a building block for the synthesis of complex organic compounds, particularly in the development of new drugs. Its structural properties make it a promising candidate for medicinal chemistry applications.
Used in Chemical Industry:
2,4,6-Cycloheptatrien-1-one, 3,5,7-tribromo-2-hydroxyis used as a reactive intermediate in the synthesis of various organic compounds. Its reactivity, due to the presence of hydroxy and bromine groups, allows for the formation of a wide range of chemical products.

Upstream product

• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 2161-40-2 2-methoxytropone 
• 3172-00-7 5-bromotropolone 
• 4584-68-3 3-bromo-2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 4636-41-3 3,7-dibromotropolone 
• 21257-90-9 2-(N,N-dimethylamino)cyclohepta-2,4,6-trien-1-one 
• 67-56-1 methanol 
• 103028-41-7 2-hydroxy-3-oxo-cyclohepta-1,4,6-triene-1,4-dicarboxylic acid 
• 7726-95-6 bromine 
• 412313-55-4 (+/-)-3,5,7-tribromo-cyclohepta-3,5-diene-1,2-dione 
• 544-25-2 Cyclohepta-1,3,5-triene 
• 2267-32-5 5,5,6,6-tetrafluoro-cyclohepta-1,3-diene 
• 1422-61-3 3,4-Dibrom-6,6,7,7-tetrafluor-cyclohepten-⁽¹⁾ 
• 2229-97-2 2-(N-methylamino)tropone 

Downstream Products

• 1582779-29-0 (S)-3,5,7-tribromo-2-((1-phenylethyl)amino)cyclohepta-2,4,6-trienone 
• 1582779-27-8 (R)-3,5,7-tribromo-2-((1-phenylethyl)amino)cyclohepta-2,4,6-trienone 

Relevant academic research and scientific papers

α-Hydroxytropolones: A new class of potent inhibitors of inositol monophosphatase and other bimetallic enzymes

Mono- and polyhydroxytropolones are potent competitive inhibitors of inositol monophosphatase. Modeling studies indicate that this inhibition occurs most probably through a novel mode of action involving the chelation of the two magnesium ions in the active site. This is consistent with experimental data. Inhibition occurs when at least three oxygen atoms are present on the seven-membered ring, and only if they are contiguous to one another. In addition, those oxygens should not be protected. The corresponding six-membered rings showed no activity. Other bimetallic enzymes such as alkaline phosphatase (APase) or dopamine β-monooxygenase (DBM) are also inhibited (in a competitive or uncompetitive manner) by hydroxytropolones.

HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF

Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.

Highly enantioselective hydroamination to six-membered rings by heterobimetallic catalysts

New bimetallic Zn/Zr salen-type systems were employed as catalysts in the asymmetric intramolecular hydroamination reaction. High enantioselectivity for the formation of piperidines of up to 98% ee were observed. This journal is the Partner Organisations

Molecular and crystallographic study of tropolone type derivatives by ab initio Hartreee-Fock calculations

The molecular structures of the ground states of tropolone, 3,5,7-tribromotropolone and 5-nitrotropolone have been calculated using Hartree-Fock and MP2 methods with the 6-31G(d,p) basis set. The geometrical parameters obtained by using the HF and MP2 methods showed good agreement with the experimental data. The crystal structure of 3,5,7-tribromotropolone, a highly substituted tropolone compound, was determined to verify and correlate the computational results.

Rhodium hydride formation in the presence of a bulky monophosphite ligand: A spectroscopic and solid-state investigation

A study has been carried out on rhodium catalyst preforming when modified with the bulky tris(2,4-di-tert-butylphenyl) phosphite, P(Obtbp)3. X-Ray crystal structure determinations of a tropolone-type precursor complex [Rh(TropBr3)(CO){P(Obtbp)3}].P(Obtbp)3· CH3COCH3 (TropBr3 = 3,5,7-tribromotropolonate) and the free P(Obtbp)3 ligand are reported. Systematic in situ IR and NMR studies of the particular rhodium phosphite modified catalyst and its precursors have led to the identification of two distinct rhodium hydride species. A {1H,31P} HMBC NMR experiment afforded clarity on the 31P NMR spectra observed under hydroformylation conditions. The species were identified as [HRh(CO)3{P(Obtbp)3}] and [HRh(CO)2{P(Obtbp)3}2]. Attention was also given to the rate of catalyst formation when starting from different rhodium precursors. The Royal Society of Chemistry 2005.