363-67-7Relevant articles and documents
α-Hydroxytropolones: A new class of potent inhibitors of inositol monophosphatase and other bimetallic enzymes
Piettre, Serge R.,Ganzhorn, Axel,Hoflack, Jan,Islam, Khalid,Hornsperger, Jean-Marie
, p. 3201 - 3204 (1997)
Mono- and polyhydroxytropolones are potent competitive inhibitors of inositol monophosphatase. Modeling studies indicate that this inhibition occurs most probably through a novel mode of action involving the chelation of the two magnesium ions in the active site. This is consistent with experimental data. Inhibition occurs when at least three oxygen atoms are present on the seven-membered ring, and only if they are contiguous to one another. In addition, those oxygens should not be protected. The corresponding six-membered rings showed no activity. Other bimetallic enzymes such as alkaline phosphatase (APase) or dopamine β-monooxygenase (DBM) are also inhibited (in a competitive or uncompetitive manner) by hydroxytropolones.
Highly enantioselective hydroamination to six-membered rings by heterobimetallic catalysts
Hussein, Lenard,Purkait, Nibadita,Biyikal, Mustafa,Tausch, Eugenia,Roesky, Peter W.,Blechert, Siegfried
supporting information, p. 3862 - 3864 (2014/04/03)
New bimetallic Zn/Zr salen-type systems were employed as catalysts in the asymmetric intramolecular hydroamination reaction. High enantioselectivity for the formation of piperidines of up to 98% ee were observed. This journal is the Partner Organisations
Rhodium hydride formation in the presence of a bulky monophosphite ligand: A spectroscopic and solid-state investigation
Crous, Renier,Datt, Michael,Foster, Douglas,Bennie, Linette,Steenkamp, Casper,Huyser, Johan,Kirsten, Leo,Steylf, Gideon,Roodt, Andreas
, p. 1108 - 1116 (2007/10/03)
A study has been carried out on rhodium catalyst preforming when modified with the bulky tris(2,4-di-tert-butylphenyl) phosphite, P(Obtbp)3. X-Ray crystal structure determinations of a tropolone-type precursor complex [Rh(TropBr3)(CO){P(Obtbp)3}].P(Obtbp)3· CH3COCH3 (TropBr3 = 3,5,7-tribromotropolonate) and the free P(Obtbp)3 ligand are reported. Systematic in situ IR and NMR studies of the particular rhodium phosphite modified catalyst and its precursors have led to the identification of two distinct rhodium hydride species. A {1H,31P} HMBC NMR experiment afforded clarity on the 31P NMR spectra observed under hydroformylation conditions. The species were identified as [HRh(CO)3{P(Obtbp)3}] and [HRh(CO)2{P(Obtbp)3}2]. Attention was also given to the rate of catalyst formation when starting from different rhodium precursors. The Royal Society of Chemistry 2005.