21643-38-9Relevant academic research and scientific papers
Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida
Stephens, Matthew D.,Yodsanit, Nisakorn,Melander, Christian
supporting information, p. 1952 - 1956 (2016/10/22)
A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate Francisella novicida. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against the Francisella sub-species F. novicida and F. philomiragia.
COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE
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Page/Page column 35, (2009/12/27)
Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 and SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.
New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships
Nakai,Konno,Kosuge,Sakuyama,Toda,Arai,Obata,Katsube,Miyamoto,Okegawa,Kawasaki
, p. 84 - 91 (2007/10/02)
(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.
Cyano-substituted biphenyl compounds and liquid crystalline dielectrics containing the same
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, (2008/06/13)
Biphenyl derivatives of the formula: STR1 wherein X is --CO--O-- or --O--CO--, R1 and R4 are alkyl of 1 to 10 carbon atoms, and one of R2 and R3 is CN and the other is H, are useful for lowering the dielectric anisotropy of liquid crystalline dielectrics.
