21743-68-0

Basic information

• Product Name: (5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID
• Synonyms: CHEMBRDG-BB 5926012;BUTTPARK 10\01-17;ART-CHEM-BB B018498;AKOS B018498;(5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID;(5-PHENYL-2H-TETRAZOL-2-YL)ACETIC ACID;5-PHENYL-2H-TETRAZOLE-2-ACETIC ACID;TIMTEC-BB SBB007104
• CAS NO: 21743-68-0
• Molecular Formula: C₉H₈N₄O₂
• Molecular Weight: 204.19
• Mol File: 21743-68-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 458.3°Cat760mmHg
• Flash Point: 230.9°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.42E-09mmHg at 25°C
• CAS DataBase Reference: (5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID(21743-68-0)
• EPA Substance Registry System: (5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID(21743-68-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 21743-68-0(Hazardous Substances Data)

Usage

General Description

(5-Phenyl-tetrazol-2-yl)-acetic acid is a chemical compound with the molecular formula C10H8N4O2. It is a derivative of tetrazole, which is a five-membered heterocyclic compound containing a nitrogen atom. (5-PHENYL-TETRAZOL-2-YL)-ACETIC ACID has potential pharmaceutical properties and is being studied for its uses in drug development. Its structure and properties make it a potential candidate for various biological and pharmacological applications. Additionally, it may have uses in research and in the development of new pharmaceuticals.

InChI:InChI=1/C9H8N4O2/c14-8(15)6-13-11-9(10-12-13)7-4-2-1-3-5-7/h1-5H,6H2,(H,14,15)/p-1

Upstream product

• 21054-65-9 5-phenyl-2-tetrazolylacetic acid ethyl ester 
• 25468-24-0 5-phenyltetrazol-2-ylethanoic acid amide 
• 100-47-0 benzonitrile 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 18039-42-4 5-Phenyl-1H-tetrazole 

Downstream Products

• 165816-78-4 2-(5-phenyl-2H-tetrazol-2-yl)acetic acid chloride 
• 93795-29-0 (5-phenyltetrazol-2-yl)acetyl azide 
• 1378894-62-2 1-(2-aminophenyl)-3-[(5-phenyl-2H-1,2,3,4-tetrazol-2-yl)methyl]urea 
• 1378894-61-1 N-phenyl-N'-(5-phenyltetrazol-2-ylmethyl)urea 
• 1010421-11-0 C₃₂H₃₅N₇O₄S 
• 407637-97-2 N-{[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}-2-(5-phenyl-2H-tetraazol-2-yl)acetamide 
• 67037-01-8 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide 
• 25468-25-1 5-phenyltetrazol-2-ylacetic acid diethylamide 
• 852312-42-6 5-phenyltetrazol-2-ylacetic acid bis(2-cyanoethyl)amide 
• 332873-85-5 5-phenyltetrazol-2-ylacetic acid piperidide 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

Synthesis of 5-Aryl-2H-tetrazoles, 5-Aryl-2H-tetrazole-2-acetic Acids, and acetic Acids as Possible Superoxide Scavengers and Antiinflammatory Agents

A series of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and acetic acids were synthesized and tested in vitro for superoxide scavenging activity, in vivo in the carrageenan-induced rat paw edema assay, and in the reverse passive Arthus reaction.The hydroxy-substituted compounds were effective as in vitro scavengers of superoxide but were not effective as in vivo antiinflammatory agents.