25468-24-0Relevant academic research and scientific papers
Aminolysis of 5-phenyl-2-tetrazolylacetic acid ethyl ester
Putis,Zubarev,Poplavskii,Ostrovskii
, p. 698 - 701 (2001)
It was shown using 5-phenyl-2-tetrazolylacetic acid ethyl ester as an example that aminolysis is a competitive method of synthesizing primary amides. The efficiency of aminolysis by primary amines is linked to the basicity of the initial amine. Highly bas
Novel N-acylurea Derivatives and Composition for Prevention or Treatment of Cardiovascular Disorders Comprising the Same
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Paragraph 0108; 0110; 0125; 0128, (2017/07/31)
The present invention relates to a novel N-acylurea derivative, and to a composition comprising the same for treating or preventing cardiovascular disorders. More particularly, the present invention relates to a novel N-acylurea derivative, a composition comprising the N-acylurea derivative as an active component for preventing or treating cardiovascular disorders, and to a preparation method of the N-acylurea derivative. According to the present invention, the N-acylurea derivative inhibits platelet coagulation by suppressing dephosphorization action of an intracellular matrix, and thus is useful for preventing or treating cardiovascular disorders.COPYRIGHT KIPO 2017
Synthesis and acidity of 5-phenyltetrazol-2-ylalkanoic acids and the corresponding 5-(5-phenyltetrazol-2-ylalkyl)tetrazoles
Esikov,Zubarev,Bezklubnaya,Malin,Ostrovskii
, p. 986 - 991 (2007/10/03)
We have obtained 5-phenyltetrazol-2-ylalkanoic acids and their derivatives containing terminal nitrile, amide, and tetrazol-5-yl groups. Tetrazolylalkanoic acids with two (pKa 4.93) and three (pKa 5.45) bridging methylene groups are
SYNTHESIS OF CYANOALKYLTETRAZOLES
Buzilova, S. R.,Brekhov, Yu. V.,Afonin, A. V.,Gareev, G. A.,Vereshchagin, L. I.
, p. 1375 - 1379 (2007/10/02)
The alkylation of 5-substituted tetrazoles with chloroacetonitrile in dioxane in the presence of potassium hydroxide and triethylbenzylammonium chloride leads to 1(2)-cyanoalkyltetrazoles. 5-Cyanoalkyltetrazoles were synthesized as a result of the substit
