21054-65-9

Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry:
ETHYL 2-(5-PHENYL-2H-1,2,3,4-TETRAAZOL-2-YL)ACETATE is utilized as a key intermediate in the synthesis of potential drug candidates, given its unique chemical structure and reactivity.
Used in Anticancer Applications:
In the field of oncology, ETHYL 2-(5-PHENYL-2H-1,2,3,4-TETRAAZOL-2-YL)ACETATE is explored as an anticancer agent, targeting various types of cancer by interfering with cellular processes that contribute to tumor growth and progression.
Used in Treatment of Ischemic Stroke:
ETHYL 2-(5-PHENYL-2H-1,2,3,4-TETRAAZOL-2-YL)ACETATE has been studied for its potential to treat ischemic stroke, suggesting a role in neuroprotection and the mitigation of stroke-induced damage.
Used as Antifungal and Antibacterial Agent:
ETHYL 2-(5-PHENYL-2H-1,2,3,4-TETRAAZOL-2-YL)ACETATE has demonstrated potential as both an antifungal and antibacterial agent, indicating its broad-spectrum activity against various pathogens, which is of interest for the development of new antimicrobial therapies.
Used in Research and Development:
ETHYL 2-(5-PHENYL-2H-1,2,3,4-TETRAAZOL-2-YL)ACETATE is a subject of interest in research for its pharmacological applications, as scientists investigate its mechanisms of action and potential therapeutic benefits across different medical conditions.

InChI:InChI=1/C11H12N4O2/c1-2-17-10(16)8-15-13-11(12-14-15)9-6-4-3-5-7-9/h3-7H,2,8H2,1H3

Upstream product

• 105-36-2 ethyl bromoacetate 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 100-47-0 benzonitrile 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 105-39-5 chloroacetic acid ethyl ester 
• 64073-60-5 potassium salt of 5-phenyltetrazole 

Downstream Products

• 25468-24-0 5-phenyltetrazol-2-ylethanoic acid amide 
• 21743-68-0 5-phenyl-2H-tetrazolylacetic acid 
• 67037-01-8 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide 
• 125707-88-2 5-phenyl-2-tetrazolylacetonitrile 
• 125707-93-9 2-(5-phenyltetrazolyl)-5-tetrazolylmethane 
• 1221230-59-6 2-carboethoxymethyl-5-phenyltetrazole-3-oxide 
• 76507-09-0 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(2-ethoxyphenyl)thiosemicarbazide 
• 76507-14-7 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(3,4-dimethylphenyl)thiosemicarbazide 
• 76507-10-3 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(4-chlorophenyl)thiosemicarbazide 
• 76507-04-5 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(2-tolyl)thiosemicarbazide 
• 76507-06-7 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(4-tolyl)thiosemicarbazide 
• 76507-05-6 1-(5-phenyl-2H-tetrazol-2-ylacetyl)-4-(3-tolyl)thiosemicarbazide 
• 76507-07-8 C₁₇H₁₇N₇O₂S 
• 76523-49-4 C₁₈H₁₉N₇O₂S 

Relevant academic research and scientific papers

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

Catalytic Synthesis of 5-Substituted Tetrazoles: Unexpected Reactions and Products

Tetrazoles are incredibly useful organic molecules with a wide range of applications from medicinal chemistry as carboxylic acid isosteres to high energy density materials in space research. In an effort to develop an easy protocol for the synthesis of te

Synthesis of 5-Aryl-2H-tetrazoles, 5-Aryl-2H-tetrazole-2-acetic Acids, and acetic Acids as Possible Superoxide Scavengers and Antiinflammatory Agents

A series of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and acetic acids were synthesized and tested in vitro for superoxide scavenging activity, in vivo in the carrageenan-induced rat paw edema assay, and in the reverse passive Arthus reaction.The hydroxy-substituted compounds were effective as in vitro scavengers of superoxide but were not effective as in vivo antiinflammatory agents.

TETRAZOLES. XIV. KINETICS AND RATIO OF PRODUCTS IN THE ALKYLATION OF SALTS OF SUBSTITUTED 5-PHENYLTETRAZOLES WITH ETHYL BROMOACETATE IN ACETONITRILE

The reaction kinetics and the product ratios were studied for the alkylation of the potassium salts of a series of substituted 5-phenyltetrazoles by ethyl bromoacetate in acetonitrile.Comparison of the obtained data with the results from investigation of the reaction of the same salts with dimethyl sulfate made it possible to consider that the alkylation of tetrazolate anions takes place by a two stage mechanism.

Carbon-13 Nuclear Magnetic Resonance Spectra of Substituted-s-triazolyl Tetrazoles

The natural abundance carbon-13 nuclear magnetic resonance spectra of various 5-aryltetrazoles, 1-(5-aryltetrazol-2-ylacetyl)-4-phenyl thiosemicarbazides and 5-(5-aryltetrazol-2-ylmethyl)-4-phenyl-s-triazole-3-thiols were recorded using Fourier transform