21744-84-3

Basic information

• Product Name: 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: BUTTPARK 148\07-41;4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE;4-METHYLBENZO[B]MORPHOLIN-3-ONE;4-(N-METHYL)-1,4-BENZOXAZINE-3-ONE;4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE, 98 %;4-Methyl-2H-1,4-Benzoxazin-3-one;4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one
• CAS NO: 21744-84-3
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• Product Categories: Miscellaneous;API intermediates;Benzoxazines;Building Blocks;Heterocyclic Building Blocks
• Mol File: 21744-84-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 57-60 °C(lit.)
• Boiling Point: 369.51 °C at 760 mmHg
• Flash Point: 177.274 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 1.18E-05mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.49±0.20(Predicted)
• CAS DataBase Reference: 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(21744-84-3)
• EPA Substance Registry System: 4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(21744-84-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 21744-84-3(Hazardous Substances Data)

Usage

Uses

4-Methyl-2H-1,4-benzoxazin-3(4H)-one may be used in the preparation of N-methyl benzomorpholine.

General Description

4-Methyl-2H-1,4-benzoxazin-3(4H)-one is a heterocyclic building block. Its C-formylation in the presence of 1,1-dichloromethyl methyl ether under Friedel-Crafts reaction conditions has been reported.

InChI:InChI=1/C9H9NO2/c1-10-7-4-2-3-5-8(7)12-6-9(10)11/h2-5H,6H2,1H3

Upstream product

• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 74-88-4 methyl iodide 
• 112689-18-6 [2-(formyl-methyl-amino)-phenoxy]-acetic acid 
• 10541-78-3 2-methoxy-N-methylaniline 
• 79-04-9 chloroacetyl chloride 
• 77-78-1 dimethyl sulfate 
• 95-55-6 2-amino-phenol 
• 611-24-5 o-(N-methylamino)phenol 
• 824-39-5 sodium o-nitrophenate 
• 20308-28-5 N-methyl-o-ethoxyaniline 
• 55860-22-5 2-chloro-N-(2-methoxyphenyl)acetamide 
• 21744-74-1 4-methyl-4H-benzo[1,4]oxazin-3-thione 
• 468055-55-2 formic acid-(2-hydroxy-N-methyl-anilide) 
• 1878-87-1 2-nitrophenoxyacetic acid 

Downstream Products

• 104057-50-3 2-benzylidene-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 7699-21-0 4-methoxy-1-methyloxindole 
• 7699-23-2 7-methoxy-1-methylindolin-2-one 
• 77901-22-5 4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 611-24-5 o-(N-methylamino)phenol 
• 103361-43-9 6-amino-4-methyl-4H-benzo[1,4]oxazin-3-one 
• 103361-68-8 6-Nitro-4-methyl-2H-1,4-benzoxazin-3(4H)-one 
• 1291093-78-1 C₁₆H₁₃BrClNO₂ 
• 1291093-79-2 7-(5-bromo-2-chloro-benzyl)-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1246684-38-7 6-[2-(2-chloro-5-methoxy-phenyl)-acetyl]-4-methyl-4H-benzo[1,4]oxazin-3-one 
• 1246684-74-1 6-[2-(2-chloro-4-methoxy-phenyl)-acetyl]-4-methyl-4H-benzo[1,4]oxazin-3-one 
• 2835-30-5 1-allyl-3-phenylurea 
• 114566-64-2 6-[2-(4-Bromo-phenylamino)-thiazol-4-yl]-4-methyl-4H-benzo[1,4]oxazin-3-one 
• 114566-63-1 6-[2-(4-Chloro-phenylamino)-thiazol-4-yl]-4-methyl-4H-benzo[1,4]oxazin-3-one 

Relevant articles and documents

Rapid N-alkylation of benzoxazinones and benzothiazinones under microwave irradiation

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Described herein are methods for using compounds that activate pyruvate kinase.

GLYCOSIDE DERIVATIVE AND USES THEREOF

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.