21859-82-5Relevant articles and documents
Oxidative organocatalytic chemoselective: N -acylation of heterocycles with aromatic and conjugated aldehydes
Ta, Linda,Sundén, Henrik
supporting information, p. 531 - 534 (2018/01/19)
Selective acylation of indoles is cumbersome often involving the need for sensitive and reactive acyl chloride derivatives or coupling reagents. Here we report a mild, functional group tolerant and highly chemoselective oxidative carbene catalyzed N-acylation of indoles with aldehydes. The acylation has a broad substrate scope and is compatible with substituents on both the aldehyde and the indole reaction partner. Furthermore, aza-heterocycles such as pyrrole and indazole can also be used as nucleophiles in this reaction providing the corresponding amide congeners in good yield.
Site-Selective Addition of Maleimide to Indole at the C-2 Position: Ru(II)-Catalyzed C-H Activation
Lanke, Veeranjaneyulu,Bettadapur, Kiran R.,Prabhu, Kandikere Ramaiah
supporting information, p. 4662 - 4665 (2015/10/12)
Synthesis of 3-(indol-2-yl)succinimide derivatives is presented using a directing group strategy. Selective functionalization of C-2 in the presence of highly reactive C-3 in indole derivatives has been achieved. A conjugate addition product instead of He
Efficient N-aroylation of substituted indoles with N-aroylbenzotriazoles
Katritzky, Alan R.,Khelashvili, Levan,Mohapatra, Prabhu P.,Steel, Peter J.
, p. 3673 - 3677 (2008/09/19)
Stable and easily accessible N-aroylbenzotriazoles react with indoles in the presence of a base to afford the corresponding N-aroylindoles in yields averaging 70%. This method is effective even when both coupling reagents possess electron-donating substit
