218914-85-3Relevant articles and documents
Synthesis of 6-fluoro-D-olivose (2,6-dideoxy-6-fluoro-D-arabino-hexopyranose)
Nieschalk, Jens,O'Hagan, David
, p. 159 - 163 (1998)
An efficient synthesis of 6-fluoro-D-olivose 5 (2,6-dideoxy-6-fluoro-D-arabino-hexopyranose) starting from D-glucose is reported. Key features of the synthesis involve the early introduction of the fluorine atom at C-6 and the Fischer reductive eliminatio
Synthesis of [18F]-6-deoxy-6-fluoro-D-glucose ([ 18F]6FDG), a potential tracer of glucose transport
Neal, Timothy R.,Schumann, William C.,Berridge, Marc S.,Landau, Bernard R.
, p. 845 - 854 (2007/10/03)
With the goal of developing a PET radioligand for the in vivo assessment of glucose transport, 6-deoxy-6-[18F]fluoro-D-glucose ([ 18F]6FDG) was prepared in two steps from 18F-. Starting with D-glucose, the tosyl- and mesyl-derivatives of 3,5-O-benzylidene-1,2-O-isopropylidene-α-D-glucofuranose were prepared by known methods. Reaction of either of these precursors with 18F - resulted in the formation of 3,5-O-benzylidene-6-deoxy-O-[ 18F]-fluoro-1,2-O-isopropylidene-α-D-glucofuranose in high yield. Subsequent hydrolysis resulted in the production of [18F]6FDG. Under optimal conditions, [18F]6FDG is produced 60-70 min after end of bombardment (EOB) in 71 ± 12% yield (decay corrected, based upon fluoride) with a radiochemical purity of ≥96%. Preliminary experiments have indicated that [18F]6FDG may be a more representative in vivo tracer for the glucose transporter than 2FDG. Copyright
