21902-35-2Relevant articles and documents
Blue thermally activated delayed fluorescence emitter using modulated triazines as electron acceptors
Lee, Youngnam,Woo, Seung-Je,Kim, Jang-Joo,Hong, Jong-In
, (2020)
Three types of thermally activated delayed fluorescence (TADF) emitters, namely, moTrSAc, tmTrSAc, and motmTrSAc, are reported that emit blue-shifted emission with high external quantum efficiencies (EQEs). These emitters have electron donating spiroacridine in common and various triazine-based electron acceptors. The electronic and structural control on the electron acceptor moiety adjusts the reduction potential of the molecule to shift the emission wavelength to the blue region. Moreover, as these emitters become widened, the light out-coupling efficiency increases due to the enhanced horizontal emitting dipole orientation. As a result, OLEDs based on moTrSAc, tmTrSAc, and motmTrSAc emit blue light in a range of 460–480 nm with high EQEs of 21.3, 15.5, and 19.5%, respectively.
A new class of 1,3,5-triazine-based selective estrogen receptor degraders (SERDs): Lead optimization, molecular docking and dynamic simulation
Huang, Ali,Lu, Xiang,Luo, Guoshun,Mao, Jiashun,Sun, Liang,Xiang, Hua,Xiao, Maoxu
, (2020/02/26)
Selective estrogen receptor degrader (SERD) that acts as not only ER antagonist, but also ER degrader, would be useful for the treatment for drug-resistance ER+ breast cancer. However, most of currently available SERD candidates involve very limited molecular scaffolds and are still in clinical trials. In this study, we introduced a 1,3,5-triazine ring into a homobibenzyl motif extracted from amounts of ER ligands and synthesized sixteen SERDs bearing acrylic acid or acrylic amide side chains that possess both ERα antagonism and degradation properties. And all compounds were screened for their anti-proliferative activity against ER+ MCF-7 and Ishikawa cell lines. Among them, compound XHA1614 displayed potent growth inhibition activity against MCF-7 and Ishikawa cells with IC50 values of 3.15 μM and 3.11 μM, respectively. Moreover, XHA1614 could dramatically degrade ER level at 1 nM in a Western blotting assay and afforded an outstanding antagonistic activity via suppressing the expression of progesterone receptor messenger RNA in MCF-7 cells in a RT-PCR assay. Further molecular docking and dynamic simulation on properly selected derivative furnished insights into its binding profile within ERα. Our findings suggest that the 1,3,5-triazine core was a feasible alternative to currently reported SERD scaffold, and provide information that will be useful for further development of promising SERDs candidates for breast cancer therapies.
BISTRIAZINE COMPOUND AND METHOD FOR PRODUCING THE SAME, AND WAVELENGTH CONVERSION EMISSION FILM PREPARED THEREWITH
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Paragraph 0181; 0182; 0183, (2018/10/16)
PROBLEM TO BE SOLVED: To provide a wavelength conversion emission film prepared with an organic fluorescent material that has high workability, has a maximum absorption wavelength in an ultraviolet region, and emits visible light. SOLUTION: A wavelength conversion emission film contains a bistriazine compound represented by formula (1a) as a component (Ar1 is a C14-22 divalent fused-ring aromatic hydrocarbon group; R1-R5 independently represent H, C1-12 alkoxy or C1-12 alkylsulfanyl). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
