21902-35-2

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 90723-86-7 2,4-dichloro-6-(4-methoxy-phenyl)-[1,3,5]triazine 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 1015814-07-9 C₃₄H₂₈N₆O₄ 
• 67014-53-3 4-(4,6-bis(4-methoxyphenyl)-1,3,5-triazin-2-yl)benzaldehyde 

Relevant academic research and scientific papers

Blue thermally activated delayed fluorescence emitter using modulated triazines as electron acceptors

Three types of thermally activated delayed fluorescence (TADF) emitters, namely, moTrSAc, tmTrSAc, and motmTrSAc, are reported that emit blue-shifted emission with high external quantum efficiencies (EQEs). These emitters have electron donating spiroacridine in common and various triazine-based electron acceptors. The electronic and structural control on the electron acceptor moiety adjusts the reduction potential of the molecule to shift the emission wavelength to the blue region. Moreover, as these emitters become widened, the light out-coupling efficiency increases due to the enhanced horizontal emitting dipole orientation. As a result, OLEDs based on moTrSAc, tmTrSAc, and motmTrSAc emit blue light in a range of 460–480 nm with high EQEs of 21.3, 15.5, and 19.5%, respectively.

Polymerizable UV absorbers for the UV stabilization of polyesters. I. Design, synthesis and polymerization of a library of UV absorbing monomers

UV stabilizers, such as Tinuvin 1577, are organic additives that are used in the polymer industry to suppress polymer photodegradation, however leaching of the stabilizers from polymers is a significant practical issue which limits the effectiveness of the stabilizers and restricts polymer lifetimes. Novel, polymerizable UV stabilizers were synthesised and copolymerized with bis(2-hydroxyethyl) isophthalate to yield poly(ethylene isophthalate) copolymers where the UV stabilizers are bound covalently into the polymer chains. This strategy prevents leaching of stabilizers from polymers over time, and is expected to lead to enhanced UV protection of polymers compared to the admixing of polymers with UV stabilizers of low molar mass.

A new class of 1,3,5-triazine-based selective estrogen receptor degraders (SERDs): Lead optimization, molecular docking and dynamic simulation

Selective estrogen receptor degrader (SERD) that acts as not only ER antagonist, but also ER degrader, would be useful for the treatment for drug-resistance ER+ breast cancer. However, most of currently available SERD candidates involve very limited molecular scaffolds and are still in clinical trials. In this study, we introduced a 1,3,5-triazine ring into a homobibenzyl motif extracted from amounts of ER ligands and synthesized sixteen SERDs bearing acrylic acid or acrylic amide side chains that possess both ERα antagonism and degradation properties. And all compounds were screened for their anti-proliferative activity against ER+ MCF-7 and Ishikawa cell lines. Among them, compound XHA1614 displayed potent growth inhibition activity against MCF-7 and Ishikawa cells with IC50 values of 3.15 μM and 3.11 μM, respectively. Moreover, XHA1614 could dramatically degrade ER level at 1 nM in a Western blotting assay and afforded an outstanding antagonistic activity via suppressing the expression of progesterone receptor messenger RNA in MCF-7 cells in a RT-PCR assay. Further molecular docking and dynamic simulation on properly selected derivative furnished insights into its binding profile within ERα. Our findings suggest that the 1,3,5-triazine core was a feasible alternative to currently reported SERD scaffold, and provide information that will be useful for further development of promising SERDs candidates for breast cancer therapies.

1,3,5-triazine compound or medicinal salt thereof as well as preparation method and application thereof

The invention discloses a 1,3,5-triazine compound of a formula (I) or a formula (II) shown in the specification, or a medicinal salt thereof, and furthermore discloses a preparation method and application of the compound or the medicinal salt thereof. The compound or the medicinal salt thereof disclosed by the invention can be adopted to prepare medicines for treating human breast cancer and endometrial cancer.

BISTRIAZINE COMPOUND AND METHOD FOR PRODUCING THE SAME, AND WAVELENGTH CONVERSION EMISSION FILM PREPARED THEREWITH

PROBLEM TO BE SOLVED: To provide a wavelength conversion emission film prepared with an organic fluorescent material that has high workability, has a maximum absorption wavelength in an ultraviolet region, and emits visible light. SOLUTION: A wavelength conversion emission film contains a bistriazine compound represented by formula (1a) as a component (Ar1 is a C14-22 divalent fused-ring aromatic hydrocarbon group; R1-R5 independently represent H, C1-12 alkoxy or C1-12 alkylsulfanyl). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

New optoelectronic materials based on bitriazines: Synthesis and properties

A series of bitriazine derivatives were synthesized for the first time by the self-coupling reactions of the monocholoro-triazines in the presence of nickel catalyst. Such bitriazines show excellent optoelectronic properties.

o-Hydroxyphenyl-s-triazines

o-Hydroxyphenyl-s-triazines are described which contain at least two alkoxyphenyl substituents. They have the formula (1). The compounds according to the invention are suitable as stabilizers for textile fiber materials, in particular polyester fiber materials, and for organic polymers. Furthermore, they are suitable for use as sunscreens in cosmetic preparations.

o-Hydroxyphenyl-s-triazines

A description is given of o-hydroxyphenyl-s-triazines containing at least two alkoxyphenyl-substituents. They have the formula (1). The compounds according to the invention are particularly suitable as sunscreen agents in cosmetic preparations.