21911-67-1

Usage

Uses

Used in Organic Synthesis:
[(3-methylphenyl)amino]acetic acid is used as a reagent in organic synthesis for its ability to participate in a range of chemical reactions, including condensation, substitution, and rearrangement reactions. Its unique structural features allow it to be a versatile building block for the creation of more complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, [(3-methylphenyl)amino]acetic acid is used as an intermediate in the synthesis of various drugs and drug candidates. Its structural properties make it a suitable candidate for the development of new medications, particularly those targeting specific biological receptors or enzymes.
Used in Chemical Research:
[(3-methylphenyl)amino]acetic acid is also utilized in chemical research as a model compound to study reaction mechanisms, explore new synthetic routes, and understand the properties of related molecules. Its reactivity and structural characteristics provide valuable insights into the behavior of similar compounds in various chemical environments.

Upstream product

• 99-08-1 1-methyl-3-nitrobenzene 
• 79-11-8 chloroacetic acid 
• 60-29-7 diethyl ether 
• 108-44-1 1-amino-3-methylbenzene 
• 105-36-2 ethyl bromoacetate 
• 21911-66-0 N-(3-methylphenyl)glycine ethyl ester 
• 100-52-7 benzaldehyde 
• 99-61-6 3-nitro-benzaldehyde 
• 619-28-3 m-nitrobenzylidene chloride 

Downstream Products

• 3483-17-8 N-(3-methylphenyl)sydnone 
• 87564-97-4 Cu(N-(m-tolyl)glycinate)2 
• 119656-40-5 N-Acetyl-N-(3-methylphenyl)glycine 

Relevant academic research and scientific papers

Exploiting Synergistic Catalysis for an Ambient Temperature Photocycloaddition to Pyrazoles

Sydnone-based cycloaddition reactions are a versatile platform for pyrazole synthesis, however they operate under harsh conditions (high temperature and long reaction times). Herein we report a strategy that addresses this limitation utilizing the synergistic combination of organocatalysis and visible-light photocatalysis. This new approach proceeds under ambient conditions and with excellent levels of regiocontrol. Mechanistic studies suggest that photoactivation of sydnones, rather than enamines, is key to the successful implementation of this process.

Synthesis and evaluation of phenyl substituted sydnones as potential DPPH-radical scavengers

A series of phenyl substituted sydnones has been synthesized and their radical-scavenging activity has been studied on DPPH free radical. Out of eighteen compounds screened, nine compounds show interesting activity. A mechanism is presented whereby sydnones scavenge DPPH radical through donating H-atom at 4th-position. Its strong radical-scavenging activity mainly arises from 1, 2, 3-oxadiazolium-5-olate ring. Different substituents and their positions on the phenyl ring differently influence DPPH scavenging activity and therefore, may provide clues to design and develop better free-radical scavenging sydnones with multiple activities.

Pyrimidin derivatives

The invention relates to new pharmaceutically active compounds which are are P2-purinoceptor 7-transmembrane (TM) G-protein coupled receptor antagonists, compositions containing them and processes for their preparation.